Effects of exercise combined with caloric restriction on inflammatory cytokines

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It has been suggested that circulating biomarkers for inflammation may be modified by exercise; however, few laboratory-based studies have been conducted in nonobese premenopausal women. The purpose of this investigation was to determine the impact of a 4-month exercise training and caloricrestriction intervention with the goal of weight loss on circulating biomarkers of inflammation in sedentary premenopausal women aged 25-40 years (weight, 57 ± 2 kg). Subjects were studied for 6 consecutive menstrual cycles: 1 Screening, 1 Baseline, then 4 interventions (Interventions 1-4). Supervised aerobic training, consisting primarily of treadmill running and elliptical machine exercise, was performed 4 times per week for 40-90 min at 79% ± 0.7% of maximal heart rate. Subjects also consumed 30% fewer calories vs. baseline (1863 ± 58 to 1428 ± 53 kcal day-1 (1 kcal = 4.186 kJ), p < 0.0001). Circulating inflammatory biomarkers, including adiponectin, high-sensitivity (hs) C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interferon-gamma (IFN-γ), and leptin, as well as body composition, aerobic capacity, and energy balance, were measured before and after the intervention. Maximal aerobic capacity increased by 8.5 ± 1.7 mL kg-1 min-1 (p < 0.001) and body mass declined by an average of 3.7 ± 0.5 kg (p < 0.001). Significant reductions in IL-6 (0.39 ± 0.04 to 0.30 ± 0.03 pg mL-1, p = 0.025), IFN-γ (0.58 ± 0.83 to 0.42 ± 0.64 pg mL-1, p=0.030),and leptin (13.18 ± 1.28 to 6.28 ± 0.71 pg mL-1, p< 0.001) were detected in response to the intervention. No significant changes in adiponectin, hs-CRP, or TNF-α were found. Weight loss in response to exercise training and caloric restriction is effective in reducing inflammatory markers, specifically IL-6 and leptin.

Original languageEnglish (US)
Pages (from-to)573-582
Number of pages10
JournalApplied Physiology, Nutrition and Metabolism
Volume35
Issue number5
DOIs
StatePublished - Nov 2 2010

Fingerprint

Caloric Restriction
Leptin
Exercise
Cytokines
Interleukin-6
Biomarkers
Adiponectin
Inflammation
C-Reactive Protein
Interferon-gamma
Weight Loss
Tumor Necrosis Factor-alpha
Menstrual Cycle
Body Composition
Running
Atherosclerosis
Chronic Disease
Heart Rate
Weights and Measures
Neoplasms

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

@article{3269549c9df042ef80784846cc2390f0,
title = "Effects of exercise combined with caloric restriction on inflammatory cytokines",
abstract = "Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It has been suggested that circulating biomarkers for inflammation may be modified by exercise; however, few laboratory-based studies have been conducted in nonobese premenopausal women. The purpose of this investigation was to determine the impact of a 4-month exercise training and caloricrestriction intervention with the goal of weight loss on circulating biomarkers of inflammation in sedentary premenopausal women aged 25-40 years (weight, 57 ± 2 kg). Subjects were studied for 6 consecutive menstrual cycles: 1 Screening, 1 Baseline, then 4 interventions (Interventions 1-4). Supervised aerobic training, consisting primarily of treadmill running and elliptical machine exercise, was performed 4 times per week for 40-90 min at 79{\%} ± 0.7{\%} of maximal heart rate. Subjects also consumed 30{\%} fewer calories vs. baseline (1863 ± 58 to 1428 ± 53 kcal day-1 (1 kcal = 4.186 kJ), p < 0.0001). Circulating inflammatory biomarkers, including adiponectin, high-sensitivity (hs) C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interferon-gamma (IFN-γ), and leptin, as well as body composition, aerobic capacity, and energy balance, were measured before and after the intervention. Maximal aerobic capacity increased by 8.5 ± 1.7 mL kg-1 min-1 (p < 0.001) and body mass declined by an average of 3.7 ± 0.5 kg (p < 0.001). Significant reductions in IL-6 (0.39 ± 0.04 to 0.30 ± 0.03 pg mL-1, p = 0.025), IFN-γ (0.58 ± 0.83 to 0.42 ± 0.64 pg mL-1, p=0.030),and leptin (13.18 ± 1.28 to 6.28 ± 0.71 pg mL-1, p< 0.001) were detected in response to the intervention. No significant changes in adiponectin, hs-CRP, or TNF-α were found. Weight loss in response to exercise training and caloric restriction is effective in reducing inflammatory markers, specifically IL-6 and leptin.",
author = "Reed, {Jennifer L.} and {De Souza}, {Mary Jane} and Nancy Williams",
year = "2010",
month = "11",
day = "2",
doi = "10.1139/H10-046",
language = "English (US)",
volume = "35",
pages = "573--582",
journal = "Applied Physiology, Nutrition and Metabolism",
issn = "1715-5312",
publisher = "National Research Council of Canada",
number = "5",

}

Effects of exercise combined with caloric restriction on inflammatory cytokines. / Reed, Jennifer L.; De Souza, Mary Jane; Williams, Nancy.

In: Applied Physiology, Nutrition and Metabolism, Vol. 35, No. 5, 02.11.2010, p. 573-582.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of exercise combined with caloric restriction on inflammatory cytokines

AU - Reed, Jennifer L.

AU - De Souza, Mary Jane

AU - Williams, Nancy

PY - 2010/11/2

Y1 - 2010/11/2

N2 - Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It has been suggested that circulating biomarkers for inflammation may be modified by exercise; however, few laboratory-based studies have been conducted in nonobese premenopausal women. The purpose of this investigation was to determine the impact of a 4-month exercise training and caloricrestriction intervention with the goal of weight loss on circulating biomarkers of inflammation in sedentary premenopausal women aged 25-40 years (weight, 57 ± 2 kg). Subjects were studied for 6 consecutive menstrual cycles: 1 Screening, 1 Baseline, then 4 interventions (Interventions 1-4). Supervised aerobic training, consisting primarily of treadmill running and elliptical machine exercise, was performed 4 times per week for 40-90 min at 79% ± 0.7% of maximal heart rate. Subjects also consumed 30% fewer calories vs. baseline (1863 ± 58 to 1428 ± 53 kcal day-1 (1 kcal = 4.186 kJ), p < 0.0001). Circulating inflammatory biomarkers, including adiponectin, high-sensitivity (hs) C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interferon-gamma (IFN-γ), and leptin, as well as body composition, aerobic capacity, and energy balance, were measured before and after the intervention. Maximal aerobic capacity increased by 8.5 ± 1.7 mL kg-1 min-1 (p < 0.001) and body mass declined by an average of 3.7 ± 0.5 kg (p < 0.001). Significant reductions in IL-6 (0.39 ± 0.04 to 0.30 ± 0.03 pg mL-1, p = 0.025), IFN-γ (0.58 ± 0.83 to 0.42 ± 0.64 pg mL-1, p=0.030),and leptin (13.18 ± 1.28 to 6.28 ± 0.71 pg mL-1, p< 0.001) were detected in response to the intervention. No significant changes in adiponectin, hs-CRP, or TNF-α were found. Weight loss in response to exercise training and caloric restriction is effective in reducing inflammatory markers, specifically IL-6 and leptin.

AB - Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It has been suggested that circulating biomarkers for inflammation may be modified by exercise; however, few laboratory-based studies have been conducted in nonobese premenopausal women. The purpose of this investigation was to determine the impact of a 4-month exercise training and caloricrestriction intervention with the goal of weight loss on circulating biomarkers of inflammation in sedentary premenopausal women aged 25-40 years (weight, 57 ± 2 kg). Subjects were studied for 6 consecutive menstrual cycles: 1 Screening, 1 Baseline, then 4 interventions (Interventions 1-4). Supervised aerobic training, consisting primarily of treadmill running and elliptical machine exercise, was performed 4 times per week for 40-90 min at 79% ± 0.7% of maximal heart rate. Subjects also consumed 30% fewer calories vs. baseline (1863 ± 58 to 1428 ± 53 kcal day-1 (1 kcal = 4.186 kJ), p < 0.0001). Circulating inflammatory biomarkers, including adiponectin, high-sensitivity (hs) C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interferon-gamma (IFN-γ), and leptin, as well as body composition, aerobic capacity, and energy balance, were measured before and after the intervention. Maximal aerobic capacity increased by 8.5 ± 1.7 mL kg-1 min-1 (p < 0.001) and body mass declined by an average of 3.7 ± 0.5 kg (p < 0.001). Significant reductions in IL-6 (0.39 ± 0.04 to 0.30 ± 0.03 pg mL-1, p = 0.025), IFN-γ (0.58 ± 0.83 to 0.42 ± 0.64 pg mL-1, p=0.030),and leptin (13.18 ± 1.28 to 6.28 ± 0.71 pg mL-1, p< 0.001) were detected in response to the intervention. No significant changes in adiponectin, hs-CRP, or TNF-α were found. Weight loss in response to exercise training and caloric restriction is effective in reducing inflammatory markers, specifically IL-6 and leptin.

UR - http://www.scopus.com/inward/record.url?scp=77958534742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958534742&partnerID=8YFLogxK

U2 - 10.1139/H10-046

DO - 10.1139/H10-046

M3 - Article

C2 - 20962912

AN - SCOPUS:77958534742

VL - 35

SP - 573

EP - 582

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

SN - 1715-5312

IS - 5

ER -