Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease

David C. Brendle, Lyndon J.O. Joseph, Mary C. Corretti, Andrew W. Gardner, Leslie I. Katzel

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelial function, which is a measure of vascular health, is impaired in patients with PAD. We examined the effects of 6 months of aerobic exercise rehabilitation on brachial artery endothelial function, assessed using high-frequency ultrasonography, and calf blood flow in 19 older PAD patients (age 69 ± 1 years, mean ± SEM) with intermittent claudication (ankle to brachial artery index of 0.73 ± 0.04). After exercise, the time to onset of claudication pain increased by 94%, from 271 ± 49 to 525 ± 80 seconds (p <0.01), and the time to maximal claudication pain increased by 43%, from 623 ± 77 to 889 ± 75 seconds (p <0.05). Exercise rehabilitation increased the flow-mediated brachial arterial diameter by 61%, from 0.18 ± 0.03 to 0.29 ± 0.04 mm (p <0.005), as well as the relative change in brachial arterial diameter from the resting state by 60%, from 4.81 ± 0.82% to 7.97 ± 1.03% (p <0.005). Maximal calf blood flow (14.2 ± 1.0 vs 19.2 ± 2.0 ml/100 ml/min; p = 0.04), and postocclusive reactive hyperemic blood flow (9.8 ± 0.8 vs 11.3 ± 0.7 ml/100 ml/min; p = 0.1) increased 35% and 15%, respectively. In conclusion, exercise rehabilitation improved ambulatory function, endothelial-dependent dilation, and calf blood flow in older PAD patients with intermittent claudication.

Original languageEnglish (US)
Pages (from-to)324-329
Number of pages6
JournalAmerican Journal of Cardiology
Volume87
Issue number3
DOIs
StatePublished - Feb 1 2001

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Exercise Therapy
Peripheral Arterial Disease
Intermittent Claudication
Brachial Artery
Arm
Exercise
Pain
Ankle
Blood Vessels
Dilatation
Ultrasonography
Rehabilitation
Morbidity
Mortality
Health

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Brendle, David C. ; Joseph, Lyndon J.O. ; Corretti, Mary C. ; Gardner, Andrew W. ; Katzel, Leslie I. / Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease. In: American Journal of Cardiology. 2001 ; Vol. 87, No. 3. pp. 324-329.
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Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease. / Brendle, David C.; Joseph, Lyndon J.O.; Corretti, Mary C.; Gardner, Andrew W.; Katzel, Leslie I.

In: American Journal of Cardiology, Vol. 87, No. 3, 01.02.2001, p. 324-329.

Research output: Contribution to journalArticle

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