Effects of feeding, fasting and refeeding on growth hormone and insulin in obese pigs

R. H. McCusker, P. J. Wangsness, L. C. Griel, J. F. Kavanaugh

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25 Scopus citations

Abstract

This study has indicated that temporal patterns of plasma GH changes were similar in lean and obese pigs with one to two secretory spikes occurring during a 6-hour period. Fasting caused increased GH in both pig strains; however, obese pigs, compared to lean, had lower GH during feeding and fasting. This depressed plasma GH of obese pigs may not be due entirely to impaired pituitary function since refeeding caused increased GH to levels similar to lean pigs. Insulin response per unit of feed intake was greater in obese pigs compared to lean. Together with higher insulin to glucose ratios, these results indicate hyperinsulinemia in the obese pigs. Overall, hormone and glucose responses were influenced by the nutritive status-fed, fasted or refed. Therefore consideration of feeding schedule was important in assessment of hormonal differences between the lean and obese pigs.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalPhysiology and Behavior
Volume35
Issue number3
DOIs
Publication statusPublished - Sep 1985

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All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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