Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice

Roopashree Narasimhaiah, Helen Marie Kamens, Marina R. Picciotto

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Rationale: The neuropeptide galanin and its receptors are expressed in brain regions implicated in the rewarding effects of natural stimuli and drugs of abuse. Galanin has been shown to attenuate neurochemical, physiological, and behavioral signs of opiate and amphetamine reinforcement. Objective: In the current study, we present evidence that galanin modulates neurochemical and behavioral correlates of cocaine response. Methods: Mice lacking the neuropeptide galanin (Gal -/-) and wild-type (Gal +/+) controls were used to analyze the effects of galanin in an unbiased conditioned place preference paradigm. We then examined cocaine-induced activation of extracellular signal-regulated kinase (ERK) activity as a marker of intracellular signaling in the mesolimbic dopaminergic pathway induced by acute cocaine administration Results: Gal -/- mice showed significantly greater conditioned place preference at a threshold dose of cocaine (3 mg/kg) than Gal +/+ mice, and this was reversed by administration of the galanin receptor agonist galnon. Consistent with the results of behavioral experiments, there was a significant increase in ERK activation in the ventral tegmental area (VTA) and nucleus accumbens (NAc) of Gal -/- mice but not Gal +/+ mice following acute, systemic cocaine injection at the threshold dose. In the NAc, but not VTA, this effect was reversed by administration of galnon. Conclusions: These data, coupled with previous studies on the effects of morphine and amphetamine, demonstrate that galanin normally attenuates drug reinforcement, potentially via modulation of the mesolimbic dopamine system.

    Original languageEnglish (US)
    Pages (from-to)95-102
    Number of pages8
    JournalPsychopharmacology
    Volume204
    Issue number1
    DOIs
    StatePublished - May 1 2009

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    Galanin
    Extracellular Signal-Regulated MAP Kinases
    Cocaine
    Galanin Receptors
    Ventral Tegmental Area
    Nucleus Accumbens
    Amphetamine
    Neuropeptides
    Opiate Alkaloids
    Tegmentum Mesencephali
    Street Drugs
    Morphine
    Dopamine
    Injections
    Brain
    Pharmaceutical Preparations

    All Science Journal Classification (ASJC) codes

    • Pharmacology

    Cite this

    Narasimhaiah, Roopashree ; Kamens, Helen Marie ; Picciotto, Marina R. / Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice. In: Psychopharmacology. 2009 ; Vol. 204, No. 1. pp. 95-102.
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    abstract = "Rationale: The neuropeptide galanin and its receptors are expressed in brain regions implicated in the rewarding effects of natural stimuli and drugs of abuse. Galanin has been shown to attenuate neurochemical, physiological, and behavioral signs of opiate and amphetamine reinforcement. Objective: In the current study, we present evidence that galanin modulates neurochemical and behavioral correlates of cocaine response. Methods: Mice lacking the neuropeptide galanin (Gal -/-) and wild-type (Gal +/+) controls were used to analyze the effects of galanin in an unbiased conditioned place preference paradigm. We then examined cocaine-induced activation of extracellular signal-regulated kinase (ERK) activity as a marker of intracellular signaling in the mesolimbic dopaminergic pathway induced by acute cocaine administration Results: Gal -/- mice showed significantly greater conditioned place preference at a threshold dose of cocaine (3 mg/kg) than Gal +/+ mice, and this was reversed by administration of the galanin receptor agonist galnon. Consistent with the results of behavioral experiments, there was a significant increase in ERK activation in the ventral tegmental area (VTA) and nucleus accumbens (NAc) of Gal -/- mice but not Gal +/+ mice following acute, systemic cocaine injection at the threshold dose. In the NAc, but not VTA, this effect was reversed by administration of galnon. Conclusions: These data, coupled with previous studies on the effects of morphine and amphetamine, demonstrate that galanin normally attenuates drug reinforcement, potentially via modulation of the mesolimbic dopamine system.",
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    Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice. / Narasimhaiah, Roopashree; Kamens, Helen Marie; Picciotto, Marina R.

    In: Psychopharmacology, Vol. 204, No. 1, 01.05.2009, p. 95-102.

    Research output: Contribution to journalArticle

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