Narcotic addicts self administered heroin intravenously for 10 days under controlled research ward conditions and were subsequently detoxified with methadone for 7 days. Plasma testosterone levels decreased significantly when heroin dosage was between 45 and 65 mg/day contrasted to predrug base line levels. Testosterone levels remained depressed during methadone withdrawal. No statistically significant changes in A.M. plasma cortisol levels were observed during both heroin acquisition and methadone withdrawal.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Pharmacology and Experimental Therapeutics|
|State||Published - Dec 1 1975|
All Science Journal Classification (ASJC) codes
- Molecular Medicine