Effects of hypnotic drugs on memory

Edward Bixler, Martin B. Scharf, Constantin R. Soldatos, David J. Mitsky, Anthony Kales

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

An original design and new task procedures were used to evaluate the effects of morning recall of flunitrazepam 2 mg and secobarbital 100 mg taken at bedtime the previous night. Both flunitrazepam and secobarbital produced anterograde amnesia on the morning following the first drug night; with flunitrazepam, this effect was still evident on the third drug night, but did not appear to be related to plasma drug concentrations. These results suggest that when patients ingest certain benzodiazepine hypnotics before or at bedtime, there may be a decrement in memory retrieval of information acquired before sleep onset or during nocturnal awakenings. Further studies are needed to determine whether the anterograde amnesia produced by benzodiazepine drugs is an aspect of state-dependent learning.

Original languageEnglish (US)
Pages (from-to)1379-1388
Number of pages10
JournalLife Sciences
Volume25
Issue number16
DOIs
StatePublished - Oct 15 1979

Fingerprint

Hypnotics and Sedatives
Flunitrazepam
Secobarbital
Anterograde Amnesia
Data storage equipment
Benzodiazepines
Pharmaceutical Preparations
Information Storage and Retrieval
Sleep
Learning
Plasmas

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bixler, E., Scharf, M. B., Soldatos, C. R., Mitsky, D. J., & Kales, A. (1979). Effects of hypnotic drugs on memory. Life Sciences, 25(16), 1379-1388. https://doi.org/10.1016/0024-3205(79)90415-6
Bixler, Edward ; Scharf, Martin B. ; Soldatos, Constantin R. ; Mitsky, David J. ; Kales, Anthony. / Effects of hypnotic drugs on memory. In: Life Sciences. 1979 ; Vol. 25, No. 16. pp. 1379-1388.
@article{6b595c97268f43b1baa3100ef33b5902,
title = "Effects of hypnotic drugs on memory",
abstract = "An original design and new task procedures were used to evaluate the effects of morning recall of flunitrazepam 2 mg and secobarbital 100 mg taken at bedtime the previous night. Both flunitrazepam and secobarbital produced anterograde amnesia on the morning following the first drug night; with flunitrazepam, this effect was still evident on the third drug night, but did not appear to be related to plasma drug concentrations. These results suggest that when patients ingest certain benzodiazepine hypnotics before or at bedtime, there may be a decrement in memory retrieval of information acquired before sleep onset or during nocturnal awakenings. Further studies are needed to determine whether the anterograde amnesia produced by benzodiazepine drugs is an aspect of state-dependent learning.",
author = "Edward Bixler and Scharf, {Martin B.} and Soldatos, {Constantin R.} and Mitsky, {David J.} and Anthony Kales",
year = "1979",
month = "10",
day = "15",
doi = "10.1016/0024-3205(79)90415-6",
language = "English (US)",
volume = "25",
pages = "1379--1388",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "16",

}

Bixler, E, Scharf, MB, Soldatos, CR, Mitsky, DJ & Kales, A 1979, 'Effects of hypnotic drugs on memory', Life Sciences, vol. 25, no. 16, pp. 1379-1388. https://doi.org/10.1016/0024-3205(79)90415-6

Effects of hypnotic drugs on memory. / Bixler, Edward; Scharf, Martin B.; Soldatos, Constantin R.; Mitsky, David J.; Kales, Anthony.

In: Life Sciences, Vol. 25, No. 16, 15.10.1979, p. 1379-1388.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of hypnotic drugs on memory

AU - Bixler, Edward

AU - Scharf, Martin B.

AU - Soldatos, Constantin R.

AU - Mitsky, David J.

AU - Kales, Anthony

PY - 1979/10/15

Y1 - 1979/10/15

N2 - An original design and new task procedures were used to evaluate the effects of morning recall of flunitrazepam 2 mg and secobarbital 100 mg taken at bedtime the previous night. Both flunitrazepam and secobarbital produced anterograde amnesia on the morning following the first drug night; with flunitrazepam, this effect was still evident on the third drug night, but did not appear to be related to plasma drug concentrations. These results suggest that when patients ingest certain benzodiazepine hypnotics before or at bedtime, there may be a decrement in memory retrieval of information acquired before sleep onset or during nocturnal awakenings. Further studies are needed to determine whether the anterograde amnesia produced by benzodiazepine drugs is an aspect of state-dependent learning.

AB - An original design and new task procedures were used to evaluate the effects of morning recall of flunitrazepam 2 mg and secobarbital 100 mg taken at bedtime the previous night. Both flunitrazepam and secobarbital produced anterograde amnesia on the morning following the first drug night; with flunitrazepam, this effect was still evident on the third drug night, but did not appear to be related to plasma drug concentrations. These results suggest that when patients ingest certain benzodiazepine hypnotics before or at bedtime, there may be a decrement in memory retrieval of information acquired before sleep onset or during nocturnal awakenings. Further studies are needed to determine whether the anterograde amnesia produced by benzodiazepine drugs is an aspect of state-dependent learning.

UR - http://www.scopus.com/inward/record.url?scp=0018636175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018636175&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(79)90415-6

DO - 10.1016/0024-3205(79)90415-6

M3 - Article

C2 - 522606

AN - SCOPUS:0018636175

VL - 25

SP - 1379

EP - 1388

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 16

ER -

Bixler E, Scharf MB, Soldatos CR, Mitsky DJ, Kales A. Effects of hypnotic drugs on memory. Life Sciences. 1979 Oct 15;25(16):1379-1388. https://doi.org/10.1016/0024-3205(79)90415-6