Effects of injectable extended-release naltrexone (XR-NTX) for opioid dependence on residential rehabilitation outcomes and early follow-up

Douglas Leslie, William Milchak, David R. Gastfriend, Philip L. Herschman, Edward Bixler, Diana L. Velott, Roger Meyer

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background and Objectives Little is known about the use of extended-release naltrexone (XR-NTX) during residential rehabilitation, and its effects on early outcomes and rates of follow-up treatment. This study examined patient characteristics and rates of treatment completion and engagement in post-residential care of opioid dependent patients who received XR-NTX during residential rehabilitation, compared with patients who did not receive this medication. Methods Electronic records for opioid dependent patients from three Pennsylvania residential detoxification and treatment facilities (N = 7,687) were retrospectively analyzed. We determined the proportion of patients who received XR-NTX (INJ), and compared rates of treatment completion and engagement in follow-up care relative to a naturalistic control group of patients recommended for, but not administered, XR-NTX (Non-INJ). Data on whether the patient initiated follow-up care were available from one site (N = 3,724). Results Overall, 598 (7.8%) patients were recommended for XR-NTX and of these, 168 (28.1%) received injections. Compared to non-INJ patients, INJ patients were less likely to leave against medical advice (4.8% vs. 30.2%, p < .001) and more likely to initiate follow-up care (37.7% vs. 19.7%, p < .001). These differences remained significant after controlling for demographic covariates using regression analysis. Conclusions XR-NTX was associated with higher rates of residential and early post-residential care engagement in patients with opioid dependence. Scientific Significance XR-NTX may be an effective adjunct in the residential treatment and aftercare of patients with opioid dependence. (Am J Addict 2015;24:265-270)

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalAmerican Journal on Addictions
Volume24
Issue number3
DOIs
StatePublished - Apr 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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