Effects of injectable extended-release naltrexone (XR-NTX) for opioid dependence on residential rehabilitation outcomes and early follow-up

Douglas Leslie, William Milchak, David R. Gastfriend, Philip L. Herschman, Edward Bixler, Diana L. Velott, Roger Meyer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and Objectives Little is known about the use of extended-release naltrexone (XR-NTX) during residential rehabilitation, and its effects on early outcomes and rates of follow-up treatment. This study examined patient characteristics and rates of treatment completion and engagement in post-residential care of opioid dependent patients who received XR-NTX during residential rehabilitation, compared with patients who did not receive this medication. Methods Electronic records for opioid dependent patients from three Pennsylvania residential detoxification and treatment facilities (N = 7,687) were retrospectively analyzed. We determined the proportion of patients who received XR-NTX (INJ), and compared rates of treatment completion and engagement in follow-up care relative to a naturalistic control group of patients recommended for, but not administered, XR-NTX (Non-INJ). Data on whether the patient initiated follow-up care were available from one site (N = 3,724). Results Overall, 598 (7.8%) patients were recommended for XR-NTX and of these, 168 (28.1%) received injections. Compared to non-INJ patients, INJ patients were less likely to leave against medical advice (4.8% vs. 30.2%, p < .001) and more likely to initiate follow-up care (37.7% vs. 19.7%, p < .001). These differences remained significant after controlling for demographic covariates using regression analysis. Conclusions XR-NTX was associated with higher rates of residential and early post-residential care engagement in patients with opioid dependence. Scientific Significance XR-NTX may be an effective adjunct in the residential treatment and aftercare of patients with opioid dependence. (Am J Addict 2015;24:265-270)

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalAmerican Journal on Addictions
Volume24
Issue number3
DOIs
StatePublished - Apr 1 2015

Fingerprint

Naltrexone
Opioid Analgesics
Injections
Aftercare
Residential Treatment
Rehabilitation
Patient Participation
Therapeutics
Regression Analysis
Demography

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Leslie, Douglas ; Milchak, William ; Gastfriend, David R. ; Herschman, Philip L. ; Bixler, Edward ; Velott, Diana L. ; Meyer, Roger. / Effects of injectable extended-release naltrexone (XR-NTX) for opioid dependence on residential rehabilitation outcomes and early follow-up. In: American Journal on Addictions. 2015 ; Vol. 24, No. 3. pp. 265-270.
@article{782bbc20862a451e9b92f9963e37f73e,
title = "Effects of injectable extended-release naltrexone (XR-NTX) for opioid dependence on residential rehabilitation outcomes and early follow-up",
abstract = "Background and Objectives Little is known about the use of extended-release naltrexone (XR-NTX) during residential rehabilitation, and its effects on early outcomes and rates of follow-up treatment. This study examined patient characteristics and rates of treatment completion and engagement in post-residential care of opioid dependent patients who received XR-NTX during residential rehabilitation, compared with patients who did not receive this medication. Methods Electronic records for opioid dependent patients from three Pennsylvania residential detoxification and treatment facilities (N = 7,687) were retrospectively analyzed. We determined the proportion of patients who received XR-NTX (INJ), and compared rates of treatment completion and engagement in follow-up care relative to a naturalistic control group of patients recommended for, but not administered, XR-NTX (Non-INJ). Data on whether the patient initiated follow-up care were available from one site (N = 3,724). Results Overall, 598 (7.8{\%}) patients were recommended for XR-NTX and of these, 168 (28.1{\%}) received injections. Compared to non-INJ patients, INJ patients were less likely to leave against medical advice (4.8{\%} vs. 30.2{\%}, p < .001) and more likely to initiate follow-up care (37.7{\%} vs. 19.7{\%}, p < .001). These differences remained significant after controlling for demographic covariates using regression analysis. Conclusions XR-NTX was associated with higher rates of residential and early post-residential care engagement in patients with opioid dependence. Scientific Significance XR-NTX may be an effective adjunct in the residential treatment and aftercare of patients with opioid dependence. (Am J Addict 2015;24:265-270)",
author = "Douglas Leslie and William Milchak and Gastfriend, {David R.} and Herschman, {Philip L.} and Edward Bixler and Velott, {Diana L.} and Roger Meyer",
year = "2015",
month = "4",
day = "1",
doi = "10.1111/ajad.12182",
language = "English (US)",
volume = "24",
pages = "265--270",
journal = "American Journal on Addictions",
issn = "1055-0496",
publisher = "Wiley-Blackwell",
number = "3",

}

Effects of injectable extended-release naltrexone (XR-NTX) for opioid dependence on residential rehabilitation outcomes and early follow-up. / Leslie, Douglas; Milchak, William; Gastfriend, David R.; Herschman, Philip L.; Bixler, Edward; Velott, Diana L.; Meyer, Roger.

In: American Journal on Addictions, Vol. 24, No. 3, 01.04.2015, p. 265-270.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of injectable extended-release naltrexone (XR-NTX) for opioid dependence on residential rehabilitation outcomes and early follow-up

AU - Leslie, Douglas

AU - Milchak, William

AU - Gastfriend, David R.

AU - Herschman, Philip L.

AU - Bixler, Edward

AU - Velott, Diana L.

AU - Meyer, Roger

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background and Objectives Little is known about the use of extended-release naltrexone (XR-NTX) during residential rehabilitation, and its effects on early outcomes and rates of follow-up treatment. This study examined patient characteristics and rates of treatment completion and engagement in post-residential care of opioid dependent patients who received XR-NTX during residential rehabilitation, compared with patients who did not receive this medication. Methods Electronic records for opioid dependent patients from three Pennsylvania residential detoxification and treatment facilities (N = 7,687) were retrospectively analyzed. We determined the proportion of patients who received XR-NTX (INJ), and compared rates of treatment completion and engagement in follow-up care relative to a naturalistic control group of patients recommended for, but not administered, XR-NTX (Non-INJ). Data on whether the patient initiated follow-up care were available from one site (N = 3,724). Results Overall, 598 (7.8%) patients were recommended for XR-NTX and of these, 168 (28.1%) received injections. Compared to non-INJ patients, INJ patients were less likely to leave against medical advice (4.8% vs. 30.2%, p < .001) and more likely to initiate follow-up care (37.7% vs. 19.7%, p < .001). These differences remained significant after controlling for demographic covariates using regression analysis. Conclusions XR-NTX was associated with higher rates of residential and early post-residential care engagement in patients with opioid dependence. Scientific Significance XR-NTX may be an effective adjunct in the residential treatment and aftercare of patients with opioid dependence. (Am J Addict 2015;24:265-270)

AB - Background and Objectives Little is known about the use of extended-release naltrexone (XR-NTX) during residential rehabilitation, and its effects on early outcomes and rates of follow-up treatment. This study examined patient characteristics and rates of treatment completion and engagement in post-residential care of opioid dependent patients who received XR-NTX during residential rehabilitation, compared with patients who did not receive this medication. Methods Electronic records for opioid dependent patients from three Pennsylvania residential detoxification and treatment facilities (N = 7,687) were retrospectively analyzed. We determined the proportion of patients who received XR-NTX (INJ), and compared rates of treatment completion and engagement in follow-up care relative to a naturalistic control group of patients recommended for, but not administered, XR-NTX (Non-INJ). Data on whether the patient initiated follow-up care were available from one site (N = 3,724). Results Overall, 598 (7.8%) patients were recommended for XR-NTX and of these, 168 (28.1%) received injections. Compared to non-INJ patients, INJ patients were less likely to leave against medical advice (4.8% vs. 30.2%, p < .001) and more likely to initiate follow-up care (37.7% vs. 19.7%, p < .001). These differences remained significant after controlling for demographic covariates using regression analysis. Conclusions XR-NTX was associated with higher rates of residential and early post-residential care engagement in patients with opioid dependence. Scientific Significance XR-NTX may be an effective adjunct in the residential treatment and aftercare of patients with opioid dependence. (Am J Addict 2015;24:265-270)

UR - http://www.scopus.com/inward/record.url?scp=84928352113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928352113&partnerID=8YFLogxK

U2 - 10.1111/ajad.12182

DO - 10.1111/ajad.12182

M3 - Article

C2 - 25655226

AN - SCOPUS:84928352113

VL - 24

SP - 265

EP - 270

JO - American Journal on Addictions

JF - American Journal on Addictions

SN - 1055-0496

IS - 3

ER -