Effects of isolated right and left ventricular stretch on regional arteriolar resistance

Robert Zelis, Matthew Lotysh, Maurice Brais, Chin Long Peng, Edward Hurley, Dean T. Mason

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Summary: In order to evaluate right and left ventricular stretch receptors without concomitantly stimulating those of the contralateral ventricle, 12 dogs were placed on total cardiopulmonary bypass. Balloons connected to compliant reservoirs were introduced into the right and left ventricles. Changes in systemic, gracilis muscle, and paw perfusion pressure at a constant flow were used as indices of systemic, muscle, and cutaneous vascular resistance. To induce left ventricular stretch, the balloon in that chanber was rapidly inflated from a mean pressure of 1.33 kPa (10 mmHg) to a mean pressure of 7.32 kPa (55 mmHg) for 15 s (6.00 kPa [45 mmHg] increment). For right ventricular stretch, the pressure was increased from 0.67 to 4.00 kPa (5 to 30 mmHg) for 30 s (3.34 kPa [25 mmHg] increment). Both left and right ventricular stretch produced a significant fall in systemic (-4.92 kPa [-37 mmHg], -36%) and gracilis muscle (-5.59 kPa [-42 mmHg],-30%) perfusion pressure, with only minimal changes in cutaneous vascular resistance (-0.80 kPa [-6 mmHg], -4%). This reflex was found to be vagally mediated, to have a low threshold for stimulation (left ventricle, 0.67 kPa [5 mmHg] increment; right ventricle, 1.33 kPa [10 mmHg] increment), and to have a neurogenic sympathetic alpha-adrenergic efferent limb. The low threshold for stimulation suggests that these reflexes may play a physiological role with changes in body position and may be important in such pathological conditions as semilunar valvular stenosis and myocardial infarction.

Original languageEnglish (US)
Pages (from-to)419-426
Number of pages8
JournalCardiovascular Research
Volume11
Issue number5
DOIs
StatePublished - Jan 1 1977

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Heart Ventricles
Pressure
Vascular Resistance
Reflex
Perfusion
Skin
Mechanoreceptors
Cardiopulmonary Bypass
Adrenergic Agents
Pathologic Constriction
Extremities
Myocardial Infarction
Dogs
Muscles
Gracilis Muscle

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Zelis, Robert ; Lotysh, Matthew ; Brais, Maurice ; Peng, Chin Long ; Hurley, Edward ; Mason, Dean T. / Effects of isolated right and left ventricular stretch on regional arteriolar resistance. In: Cardiovascular Research. 1977 ; Vol. 11, No. 5. pp. 419-426.
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Effects of isolated right and left ventricular stretch on regional arteriolar resistance. / Zelis, Robert; Lotysh, Matthew; Brais, Maurice; Peng, Chin Long; Hurley, Edward; Mason, Dean T.

In: Cardiovascular Research, Vol. 11, No. 5, 01.01.1977, p. 419-426.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Effects of isolated right and left ventricular stretch on regional arteriolar resistance

AU - Zelis, Robert

AU - Lotysh, Matthew

AU - Brais, Maurice

AU - Peng, Chin Long

AU - Hurley, Edward

AU - Mason, Dean T.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Summary: In order to evaluate right and left ventricular stretch receptors without concomitantly stimulating those of the contralateral ventricle, 12 dogs were placed on total cardiopulmonary bypass. Balloons connected to compliant reservoirs were introduced into the right and left ventricles. Changes in systemic, gracilis muscle, and paw perfusion pressure at a constant flow were used as indices of systemic, muscle, and cutaneous vascular resistance. To induce left ventricular stretch, the balloon in that chanber was rapidly inflated from a mean pressure of 1.33 kPa (10 mmHg) to a mean pressure of 7.32 kPa (55 mmHg) for 15 s (6.00 kPa [45 mmHg] increment). For right ventricular stretch, the pressure was increased from 0.67 to 4.00 kPa (5 to 30 mmHg) for 30 s (3.34 kPa [25 mmHg] increment). Both left and right ventricular stretch produced a significant fall in systemic (-4.92 kPa [-37 mmHg], -36%) and gracilis muscle (-5.59 kPa [-42 mmHg],-30%) perfusion pressure, with only minimal changes in cutaneous vascular resistance (-0.80 kPa [-6 mmHg], -4%). This reflex was found to be vagally mediated, to have a low threshold for stimulation (left ventricle, 0.67 kPa [5 mmHg] increment; right ventricle, 1.33 kPa [10 mmHg] increment), and to have a neurogenic sympathetic alpha-adrenergic efferent limb. The low threshold for stimulation suggests that these reflexes may play a physiological role with changes in body position and may be important in such pathological conditions as semilunar valvular stenosis and myocardial infarction.

AB - Summary: In order to evaluate right and left ventricular stretch receptors without concomitantly stimulating those of the contralateral ventricle, 12 dogs were placed on total cardiopulmonary bypass. Balloons connected to compliant reservoirs were introduced into the right and left ventricles. Changes in systemic, gracilis muscle, and paw perfusion pressure at a constant flow were used as indices of systemic, muscle, and cutaneous vascular resistance. To induce left ventricular stretch, the balloon in that chanber was rapidly inflated from a mean pressure of 1.33 kPa (10 mmHg) to a mean pressure of 7.32 kPa (55 mmHg) for 15 s (6.00 kPa [45 mmHg] increment). For right ventricular stretch, the pressure was increased from 0.67 to 4.00 kPa (5 to 30 mmHg) for 30 s (3.34 kPa [25 mmHg] increment). Both left and right ventricular stretch produced a significant fall in systemic (-4.92 kPa [-37 mmHg], -36%) and gracilis muscle (-5.59 kPa [-42 mmHg],-30%) perfusion pressure, with only minimal changes in cutaneous vascular resistance (-0.80 kPa [-6 mmHg], -4%). This reflex was found to be vagally mediated, to have a low threshold for stimulation (left ventricle, 0.67 kPa [5 mmHg] increment; right ventricle, 1.33 kPa [10 mmHg] increment), and to have a neurogenic sympathetic alpha-adrenergic efferent limb. The low threshold for stimulation suggests that these reflexes may play a physiological role with changes in body position and may be important in such pathological conditions as semilunar valvular stenosis and myocardial infarction.

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JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

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