Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt

Qi Fu, Satoshi Iwase, Yuki Niimi, Atsunori Kamiya, Jun Kawanokuchi, Jian Cui, Tadaaki Mano, Akio Suzumura

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The present study was performed to test the hypothesis that application of lower body positive pressure (LBPP) during orthostasis would reduce the baroreflex-mediated enhancement in sympathetic activity in humans. Eight healthy young men were exposed to a 70° head-up tilt (HUT) on application of 30 mmHg LBPP. Muscle sympathetic nerve activity (MSNA) was microneurographically recorded from the tibial nerve, along with hemodynamic variables. We found that in the supine position with LBPP, MSNA remained unchanged (13.4 ± 3.3 vs. 11.8 ± 2.3 bursts/min, without vs. with LBPP; P > 0.05), mean arterial pressure was elevated, but arterial pulse pressure and heart rate did not alter. At 70° HUT with LBPP, the enhanced MSNA response was reduced (33.8 ± 5.0 vs. 22.5 ± 2.2 bursts/min, without vs. with LBPP; P < 0.05), mean arterial pressure was higher, the decreased pulse pressure was restored, and the increased heart rate was attenuated. We conclude that the baroreflex-mediated enhancement in sympathetic activity during HUT was reduced by LBPP. Application of LBPP in HUT induced an obvious cephalad fluid shift as well as a restoration of arterial pulse pressure, which reduced the inhibition of the baroreceptors. However, the activation of the intramuscular mechanoreflexes produced by 30 mmHg LBPP might counteract the effects of baroreflexes.

Original languageEnglish (US)
Pages (from-to)R778-R785
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume281
Issue number3 50-3
StatePublished - Oct 2 2001

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Head
Pressure
Muscles
Baroreflex
Arterial Pressure
Heart Rate
Blood Pressure
Fluid Shifts
Tibial Nerve
Pressoreceptors
Supine Position
Dizziness
Human Activities
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Fu, Qi ; Iwase, Satoshi ; Niimi, Yuki ; Kamiya, Atsunori ; Kawanokuchi, Jun ; Cui, Jian ; Mano, Tadaaki ; Suzumura, Akio. / Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2001 ; Vol. 281, No. 3 50-3. pp. R778-R785.
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Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt. / Fu, Qi; Iwase, Satoshi; Niimi, Yuki; Kamiya, Atsunori; Kawanokuchi, Jun; Cui, Jian; Mano, Tadaaki; Suzumura, Akio.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 281, No. 3 50-3, 02.10.2001, p. R778-R785.

Research output: Contribution to journalArticle

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T1 - Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt

AU - Fu, Qi

AU - Iwase, Satoshi

AU - Niimi, Yuki

AU - Kamiya, Atsunori

AU - Kawanokuchi, Jun

AU - Cui, Jian

AU - Mano, Tadaaki

AU - Suzumura, Akio

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N2 - The present study was performed to test the hypothesis that application of lower body positive pressure (LBPP) during orthostasis would reduce the baroreflex-mediated enhancement in sympathetic activity in humans. Eight healthy young men were exposed to a 70° head-up tilt (HUT) on application of 30 mmHg LBPP. Muscle sympathetic nerve activity (MSNA) was microneurographically recorded from the tibial nerve, along with hemodynamic variables. We found that in the supine position with LBPP, MSNA remained unchanged (13.4 ± 3.3 vs. 11.8 ± 2.3 bursts/min, without vs. with LBPP; P > 0.05), mean arterial pressure was elevated, but arterial pulse pressure and heart rate did not alter. At 70° HUT with LBPP, the enhanced MSNA response was reduced (33.8 ± 5.0 vs. 22.5 ± 2.2 bursts/min, without vs. with LBPP; P < 0.05), mean arterial pressure was higher, the decreased pulse pressure was restored, and the increased heart rate was attenuated. We conclude that the baroreflex-mediated enhancement in sympathetic activity during HUT was reduced by LBPP. Application of LBPP in HUT induced an obvious cephalad fluid shift as well as a restoration of arterial pulse pressure, which reduced the inhibition of the baroreceptors. However, the activation of the intramuscular mechanoreflexes produced by 30 mmHg LBPP might counteract the effects of baroreflexes.

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