Objective: To observe the effects of lysophosphatidic acid (LPA) on arrhythmia in acute myocardial infarction (AMI) rats. Methods: AMI mode ls were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups: sham-operated (SO), AMI, AMI + LPA, AMI + pertussis toxin (PTX) and AMI+PTX+LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results: Inci dence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group (P<0.01). Incidence of tachycardia and VPBs of unit time in AMI+LPA group were increased compared with AMI group (P<0.05). Incidence of tachycardia and VPBs of unit time in AMI+PTX group were decreased compared with AMI+ LPA group, it showed the effect was blocked by PTX, a G-protein-coupled receptor blocking agent. Conclusion: LPA can promote the occurrence of arrhythmi a in AMI rats.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Jilin University Medicine Edition|
|State||Published - May 1 2006|
All Science Journal Classification (ASJC) codes