EFFECTS OF METHYL AND FLUORINE SUBSTITUTION ON THE METABOLIC ACTIVATION AND TUMORIGENICITY OF POLYCYCLIC AROMATIC HYDROCARBONS.

48 Scopus citations
Original languageEnglish (US)
Title of host publicationACS Symposium Series
EditorsRonald G. Harvey
PublisherACS
Pages85-105
Number of pages21
ISBN (Print)0841209243
Publication statusPublished - Dec 1 1985

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

@inproceedings{baa022539e9d4a828164376ad013b75e,
title = "EFFECTS OF METHYL AND FLUORINE SUBSTITUTION ON THE METABOLIC ACTIVATION AND TUMORIGENICITY OF POLYCYCLIC AROMATIC HYDROCARBONS.",
abstract = "The effects of methyl and fluorine substitution on the metabolic activation and tumorigenicity of polycyclic aromatic hydrocarbons (PAH) are reviewed. The structural requirements favoring tumorigenicity of methylated PAH are a bay region methyl group and a free peri position, both adjacent to an unsubstituted angular ring. The enhancing effect of a bay region methyl group on PAH tumorigenicity appears to be due to the relatively high reactivity with DNA and exceptional tumorigenicity of a dihydrodiol epoxide metabolite having a methyl group and epoxide ring in the same bay region.",
author = "Hecht, {Stephen S.} and Shantu Amin and Melikian, {Assieh A.} and LaVoie, {Edmond J.} and Dietrich Hoffmann",
year = "1985",
month = "12",
day = "1",
language = "English (US)",
isbn = "0841209243",
series = "ACS Symposium Series",
publisher = "ACS",
pages = "85--105",
editor = "Harvey, {Ronald G.}",
booktitle = "ACS Symposium Series",

}