Effects of MIR137 on fronto-amygdala functional connectivity

Omar Mothersill, Derek W. Morris, Sinead Kelly, Emma Jane Rose, Ciara Fahey, Carol O'Brien, Ronan Lyne, Richard Reilly, Michael Gill, Aiden P. Corvin, Gary Donohoe

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with schizophrenia, and with altered amygdala activation in those at genetic risk for schizophrenia. Following this evidence, we investigated the effects of MIR137 genotype on neuronal activity during face processing. Methods: By grouping 81 healthy participants as carrier or non-carriers of the MIR137 rs1625579 risk allele associated with schizophrenia, we investigated MIR137's effects on altered cortical response during an fMRI face processing task and altered functional connectivity using the amygdala as a seed region. Results: Homozygous carriers of the risk allele were observed to show relatively increased functional connectivity between the right amygdala and frontal regions that play a key role in emotion processing and regulation (e.g. the cingulate and prefrontal cortex). Conclusions: Our findings provide the first evidence that the rs1625579 variant affects fronto-amygdala functional connectivity, providing further evidence that MIR137 may contribute to forms of psychosis in which affective symptoms are more prominent.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalNeuroImage
Volume90
DOIs
StatePublished - Apr 15 2014

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Amygdala
Schizophrenia
Alleles
Affective Symptoms
Gyrus Cinguli
Neurogenesis
Prefrontal Cortex
MicroRNAs
Psychotic Disorders
Seeds
Healthy Volunteers
Emotions
Genotype
Magnetic Resonance Imaging
Genome
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Mothersill, O., Morris, D. W., Kelly, S., Rose, E. J., Fahey, C., O'Brien, C., ... Donohoe, G. (2014). Effects of MIR137 on fronto-amygdala functional connectivity. NeuroImage, 90, 189-195. https://doi.org/10.1016/j.neuroimage.2013.12.019
Mothersill, Omar ; Morris, Derek W. ; Kelly, Sinead ; Rose, Emma Jane ; Fahey, Ciara ; O'Brien, Carol ; Lyne, Ronan ; Reilly, Richard ; Gill, Michael ; Corvin, Aiden P. ; Donohoe, Gary. / Effects of MIR137 on fronto-amygdala functional connectivity. In: NeuroImage. 2014 ; Vol. 90. pp. 189-195.
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Mothersill, O, Morris, DW, Kelly, S, Rose, EJ, Fahey, C, O'Brien, C, Lyne, R, Reilly, R, Gill, M, Corvin, AP & Donohoe, G 2014, 'Effects of MIR137 on fronto-amygdala functional connectivity', NeuroImage, vol. 90, pp. 189-195. https://doi.org/10.1016/j.neuroimage.2013.12.019

Effects of MIR137 on fronto-amygdala functional connectivity. / Mothersill, Omar; Morris, Derek W.; Kelly, Sinead; Rose, Emma Jane; Fahey, Ciara; O'Brien, Carol; Lyne, Ronan; Reilly, Richard; Gill, Michael; Corvin, Aiden P.; Donohoe, Gary.

In: NeuroImage, Vol. 90, 15.04.2014, p. 189-195.

Research output: Contribution to journalArticle

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AU - Lyne, Ronan

AU - Reilly, Richard

AU - Gill, Michael

AU - Corvin, Aiden P.

AU - Donohoe, Gary

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N2 - Background: MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with schizophrenia, and with altered amygdala activation in those at genetic risk for schizophrenia. Following this evidence, we investigated the effects of MIR137 genotype on neuronal activity during face processing. Methods: By grouping 81 healthy participants as carrier or non-carriers of the MIR137 rs1625579 risk allele associated with schizophrenia, we investigated MIR137's effects on altered cortical response during an fMRI face processing task and altered functional connectivity using the amygdala as a seed region. Results: Homozygous carriers of the risk allele were observed to show relatively increased functional connectivity between the right amygdala and frontal regions that play a key role in emotion processing and regulation (e.g. the cingulate and prefrontal cortex). Conclusions: Our findings provide the first evidence that the rs1625579 variant affects fronto-amygdala functional connectivity, providing further evidence that MIR137 may contribute to forms of psychosis in which affective symptoms are more prominent.

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Mothersill O, Morris DW, Kelly S, Rose EJ, Fahey C, O'Brien C et al. Effects of MIR137 on fronto-amygdala functional connectivity. NeuroImage. 2014 Apr 15;90:189-195. https://doi.org/10.1016/j.neuroimage.2013.12.019