Effects of nadolol and propranolol on plasma lidocaine clearance

Dennis W. Schneck, John R. Luderer, Dwight Davis, Jean Vary

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Abstract

Nadolol and propranolol effects on lidocaine elimination were followed in six healthy men and women. Each received three separate 30-hr infusions of lidocaine (2 mg/min): one alone, one after 3 days pretreatment with nadolol (160 mg daily), and one after 3 days pretreatment with propranolol (80 mg every 8 hr). Liver blood flow was determined by the systemic clearance of indocyanine green. Steady-state plasma lidocaine levels were increased by nadolol (2.1 ± 0.2 to 2.7 ± 0.3 μg/ml and by propranolol (2.1 ± 0.2 to 2.5 ± 0.3 μg/ml). Lidocaine plasma clearance was decreased by nadolol (1030 ± 81 to 850± 82 ml/min) and by propranolol (1030 ± 81 to 866 ± 75 ml/min). Hepatic blood flow was decreased by nadolol (1275 ± 77 to 902 ± 102 ml/min) and propranolol (1275 ± 77 to 957 ± 119 ml/min). The hepatic extraction ratio for lidocaine was increased by nadolol (0.86 ± 0.06 to 0.91 ± 0.05) and by propranolol (0.86 ± 0.06 to 0.90 ± 0.06). Lidocaine intrinsic clearance was not changed by nadolol (8.19 ± 1.87 to 9.52 ± 2.36 l/min) or propranolol (8.19 ± 1.87 to 9.50 ± 3.13 l/min). Our data indicate that both nadolol and propranolol reduce lidocaine clearance by their effects on hepatic blood flow and not by inhibition of lidocaine metabolism.

Original languageEnglish (US)
Pages (from-to)584-587
Number of pages4
JournalClinical pharmacology and therapeutics
Volume36
Issue number5
DOIs
StatePublished - Nov 1984

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Nadolol
Lidocaine
Propranolol
Liver
Indocyanine Green

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Schneck, Dennis W. ; Luderer, John R. ; Davis, Dwight ; Vary, Jean. / Effects of nadolol and propranolol on plasma lidocaine clearance. In: Clinical pharmacology and therapeutics. 1984 ; Vol. 36, No. 5. pp. 584-587.
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Effects of nadolol and propranolol on plasma lidocaine clearance. / Schneck, Dennis W.; Luderer, John R.; Davis, Dwight; Vary, Jean.

In: Clinical pharmacology and therapeutics, Vol. 36, No. 5, 11.1984, p. 584-587.

Research output: Contribution to journalArticle

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AU - Schneck, Dennis W.

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N2 - Nadolol and propranolol effects on lidocaine elimination were followed in six healthy men and women. Each received three separate 30-hr infusions of lidocaine (2 mg/min): one alone, one after 3 days pretreatment with nadolol (160 mg daily), and one after 3 days pretreatment with propranolol (80 mg every 8 hr). Liver blood flow was determined by the systemic clearance of indocyanine green. Steady-state plasma lidocaine levels were increased by nadolol (2.1 ± 0.2 to 2.7 ± 0.3 μg/ml and by propranolol (2.1 ± 0.2 to 2.5 ± 0.3 μg/ml). Lidocaine plasma clearance was decreased by nadolol (1030 ± 81 to 850± 82 ml/min) and by propranolol (1030 ± 81 to 866 ± 75 ml/min). Hepatic blood flow was decreased by nadolol (1275 ± 77 to 902 ± 102 ml/min) and propranolol (1275 ± 77 to 957 ± 119 ml/min). The hepatic extraction ratio for lidocaine was increased by nadolol (0.86 ± 0.06 to 0.91 ± 0.05) and by propranolol (0.86 ± 0.06 to 0.90 ± 0.06). Lidocaine intrinsic clearance was not changed by nadolol (8.19 ± 1.87 to 9.52 ± 2.36 l/min) or propranolol (8.19 ± 1.87 to 9.50 ± 3.13 l/min). Our data indicate that both nadolol and propranolol reduce lidocaine clearance by their effects on hepatic blood flow and not by inhibition of lidocaine metabolism.

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