Effects of nadolol on blood pressure, sleep efficiency, and sleep stages

Anthony Kales, Edward Bixler, Antonio Vela-Bueno, Roger J. Cadieux, Rocco L. Manfredi, Sally Bitzer, Theodore Kantner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effects of nadolol (20 and 80 mg) on blood pressure and sleep parameters were assessed in six patients with mild hypertension. A 32-night experimental protocol in the sleep laboratory was instituted consisting of four placebo-baseline nights followed by 4 weeks of drug administration. Both doses of nadolol had a clear-cut and consistent lowering effect on blood pressure throughout the night and during the day, with a greater reduction noted with the 80 mg dose. In fact, blood pressure values were reduced to normotensive levels. Neither dose had a disrupting effect on sleep, whereas the 80 mg dose improved sleep efficiency and also had a rapid eye movement-enhancing effect. This absence of sleep-disrupting effects is attributed to nadolol's low level of lipophilicity and lack of intrinsic sympathomimetic activity. The clinical significance of the lack of sleep disruption and possible improvement of sleep with nadolol is discussed in light of the well-recognized sleep disturbances produced by other β-blockers.

Original languageEnglish (US)
Pages (from-to)655-662
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume43
Issue number6
DOIs
StatePublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Effects of nadolol on blood pressure, sleep efficiency, and sleep stages'. Together they form a unique fingerprint.

  • Cite this

    Kales, A., Bixler, E., Vela-Bueno, A., Cadieux, R. J., Manfredi, R. L., Bitzer, S., & Kantner, T. (1988). Effects of nadolol on blood pressure, sleep efficiency, and sleep stages. Clinical Pharmacology and Therapeutics, 43(6), 655-662. https://doi.org/10.1038/clpt.1988.91