EFFECTS OF NALOXONE ON GLUCOSE LEVEL IN THE HEPATIC VENOUS PLASMA IN THE RAT

Piotr Pacula, Piotr Janicki, Pawel Krząścik

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume14
Issue number11-12
DOIs
StatePublished - 1987

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Naloxone
Glucose
Liver
Opioid Receptors
Opioid Analgesics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

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abstract = "1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.",
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EFFECTS OF NALOXONE ON GLUCOSE LEVEL IN THE HEPATIC VENOUS PLASMA IN THE RAT. / Pacula, Piotr; Janicki, Piotr; Krząścik, Pawel.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 14, No. 11-12, 1987, p. 911-913.

Research output: Contribution to journalArticle

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T1 - EFFECTS OF NALOXONE ON GLUCOSE LEVEL IN THE HEPATIC VENOUS PLASMA IN THE RAT

AU - Pacula, Piotr

AU - Janicki, Piotr

AU - Krząścik, Pawel

PY - 1987

Y1 - 1987

N2 - 1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.

AB - 1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.

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