1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.
|Original language||English (US)|
|Number of pages||3|
|Journal||Clinical and Experimental Pharmacology and Physiology|
|State||Published - 1987|
All Science Journal Classification (ASJC) codes
- Physiology (medical)