EFFECTS OF NALOXONE ON GLUCOSE LEVEL IN THE HEPATIC VENOUS PLASMA IN THE RAT

Piotr Pacula, Piotr Janicki, Pawel Krząścik

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume14
Issue number11-12
DOIs
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'EFFECTS OF NALOXONE ON GLUCOSE LEVEL IN THE HEPATIC VENOUS PLASMA IN THE RAT'. Together they form a unique fingerprint.

Cite this