Effects of palmatine hydrochloride mediated photodynamic therapy on oral squamous cell carcinoma

Feng Qi, Yi Sun, Moyang Lv, Feng Qin, Wenwu Cao, Liangjia Bi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Oral squamous cell carcinoma (OSCC) is a common malignant tumor, accounting for about 7% of all malignant tumors. Palmatine hydrochloride (PaH) is the alkaloid constituent of Fibraurea tinctoria Lour. The present study aims to investigate the antitumor effect of photodynamic therapy (PDT) with PaH (PaH-PDT) on human OSCC cell lines both in vitro and in vivo. The results indicate that PaH-PDT exhibited a potent phototoxic effect in cell proliferation and produced cell apoptosis. PaH-PDT increased the percentage of cells in the G0/G1 phase and decreased the CDK2 and Cyclin E1 protein level. In addition, PaH-PDT markedly increased the generation of intracellular ROS, which can be suppressed using the ROS scavenger N-acetylcysteine (NAC). Furthermore, PaH-PDT increased the expression of p53 protein in vitro and in vivo. In vivo experiments revealed that the PaH-PDT resulted in an effective inhibition of tumor growth and prolonged the survival time of tumor-bearing mice. Moreover, no obvious signs of side effects or a drop in body weight was observed. These results suggested that PaH was a promising sensitizer that can be combined with light to produce significant anti-tumor effects in oral squamous cell carcinoma via enhanced ROS production and up-regulated expression of p53.

Original languageEnglish (US)
Pages (from-to)1596-1605
Number of pages10
JournalPhotochemical and Photobiological Sciences
Volume18
Issue number6
DOIs
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry

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