Effects of particle size and ligand density on the kinetics of receptor-mediated endocytosis of nanoparticles

Hongyan Yuan, Sulin Zhang

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

We elucidate, from thermodynamic arguments, the governing factors of receptor-mediated endocytosis of nanoparticles (NPs). We show that the endocytic energetics specifies a minimal particle size and a minimal ligand density below which endocytosis is not possible. Due to the entropic penalty involved in ligand-receptor binding, endocytosis may occur with a large fraction of ligands unbound with receptors. Our analyses suggest that the endocytic time depends interrelatedly on the particle size and ligand density. There exists an optimal condition at which the endocytic time minimizes. These findings may provide valuable guidance to the rational designs of NP-based biomarkers and anticancer bioagents.

Original languageEnglish (US)
Article number033704
JournalApplied Physics Letters
Volume96
Issue number3
DOIs
StatePublished - Mar 29 2010

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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