Effects of pulsatile and nonpulsatile perfusion on vital organ recovery in pediatric heart surgery: A pilot clinical study

Tijen Alkan, Atif Akçevin, Akif Undar, Halil Türkoǧlu, Tufan Paker, Aydin Aytaç

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The use of pulsatile flow during cardiopulmonary bypass (CPB) with regard to improved patient outcomes is controversial. We evaluated pulsatile perfusion in pediatric patients undergoing CPB in a clinical setting.Fifty consecutive pediatric patients undergoing open heart surgery for repair of congenital heart disease were prospectively entered into the study and randomly assigned to either the pulsatile perfusion group (group P, n = 25) or the nonpulsatile perfusion group (group NP, n = 25). Study parameters included intubation time, duration of intensive care unit (ICU) stay and hospital stay, need for inotropic support, preoperative and postoperative enzymes, creatinine, C-reactive protein, blood count, mean urine output, and total drainage.Group P, compared with group NP, had significantly less inotropic support (number of agents, 1.48 ± 1.05 versus 2.44 ± 1.03, p = 0.0015; dopamine, 6.48 ± 3.27 versus 10.3 ± 4.8 μg/kg per minute, p = 0.0023; dobutamine, 3.12 ± 6.55 versus 8.03 ± 9.1 μg/kg per minute, p = 0.034), shorter intubation period (20.36 ± 17.02 versus 35.44 ± 30.72 hours, p = 0.038), and shorter duration of ICU stay (2.16 ± 1.07 versus 4.32 ± 4.21 days, p = 0.028) and hospital stay (7.64 ± 2.48 versus 11.84 ± 6.82 days, p = 0.007).There were no significant differences in creatinine, enzyme levels, or drainage amounts between the two groups. Higher urine output during CPB (553.6 ± 150.89 versus 465.8 ± 151.23 ml/d, p = 0.045) and during the ICU period (658.8 ± 210.99 versus 528,2 ± 224.71 ml/d, p = 0.039) was observed in group P compared with group NP.We concluded that the use of pulsatile flow resulted in improved patient outcome in preserving cardiac function and maintaining better renal and pulmonic function (shorter intubation period) in the early postbypass period.

Original languageEnglish (US)
Pages (from-to)530-535
Number of pages6
JournalASAIO Journal
Issue number5
StatePublished - Sep 1 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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