Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance

Slobodanka Pejovic, Maria Basta, Alexandros Vgontzas, Ilia Kritikou, Michele L. Shaffer, Marina Tsaoussoglou, David Stiffler, Zacharias Stefanakis, Edward Bixler, George P. Chrousos

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

One workweek of mild sleep restriction adversely impacts sleepiness, performance, and proinflammatory cytokines. Many individuals try to overcome these adverse effects by extending their sleep on weekends. To assess whether extended recovery sleep reverses the effects of mild sleep restriction on sleepiness/alertness, inflammation, and stress hormones, 30 healthy young men and women (mean age ± SD, 24.7 ± 3.5 yr; mean body mass index ± SD, 23.6 ± 2.4 kg/m2) participated in a sleep laboratory experiment of 13 nights [4 baseline nights (8 h/night), followed by 6 sleep restriction nights (6 h/night) and 3 recovery nights (10 h/night)]. Twenty-four-hour profiles of circulating IL-6 and cortisol, objective and subjective daytime sleepiness (Multiple Sleep Latency Test and Stanford Sleepiness Scale), and performance (Psychomotor Vigilance Task) were assessed on days 4 (baseline), 10 (after 1 wk of sleep restriction), and 13 (after 2 nights of recovery sleep). Serial 24-h IL-6 plasma levels increased significantly during sleep restriction and returned to baseline after recovery sleep. Serial 24-h cortisol levels during restriction did not change compared with baseline, but after recovery they were significantly lower. Subjective and objective sleepiness increased significantly after restriction and returned to baseline after recovery. In contrast, performance deteriorated significantly after restriction and did not improve after recovery. Extended recovery sleep over the weekend reverses the impact of one work week of mild sleep restriction on daytime sleepiness, fatigue, and IL-6 levels, reduces cortisol levels, but does not correct performance deficits. The long-term effects of a repeated sleep restriction/sleep recovery weekly cycle in humans remain unknown.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume305
Issue number7
DOIs
StatePublished - Oct 1 2013

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Hydrocortisone
Interleukin-6
Sleep
Psychomotor Performance
Fatigue
Body Mass Index
Hormones
Cytokines
Inflammation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Pejovic, Slobodanka ; Basta, Maria ; Vgontzas, Alexandros ; Kritikou, Ilia ; Shaffer, Michele L. ; Tsaoussoglou, Marina ; Stiffler, David ; Stefanakis, Zacharias ; Bixler, Edward ; Chrousos, George P. / Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance. In: American Journal of Physiology - Endocrinology and Metabolism. 2013 ; Vol. 305, No. 7.
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Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance. / Pejovic, Slobodanka; Basta, Maria; Vgontzas, Alexandros; Kritikou, Ilia; Shaffer, Michele L.; Tsaoussoglou, Marina; Stiffler, David; Stefanakis, Zacharias; Bixler, Edward; Chrousos, George P.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 305, No. 7, 01.10.2013.

Research output: Contribution to journalArticle

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AU - Chrousos, George P.

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