TY - JOUR
T1 - Effects of stress throughout the lifespan on the brain, behaviour and cognition
AU - Lupien, Sonia J.
AU - McEwen, Bruce S.
AU - Gunnar, Megan R.
AU - Heim, Christine
PY - 2009/6
Y1 - 2009/6
N2 - Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health. However, the specific effects on the brain, behaviour and cognition emerge as a function of the timing and the duration of the exposure, and some also depend on the interaction between gene effects and previous exposure to environmental adversity. Advances in animal and human studies have made it possible to synthesize these findings, and in this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.
AB - Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health. However, the specific effects on the brain, behaviour and cognition emerge as a function of the timing and the duration of the exposure, and some also depend on the interaction between gene effects and previous exposure to environmental adversity. Advances in animal and human studies have made it possible to synthesize these findings, and in this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.
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U2 - 10.1038/nrn2639
DO - 10.1038/nrn2639
M3 - Review article
C2 - 19401723
AN - SCOPUS:67349157695
SN - 1471-003X
VL - 10
SP - 434
EP - 445
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 6
ER -
