Effects of strontium on bone strength, density, volume, and microarchitecture in laying hens

Mohammad Shahnazari, Neil Sharkey, Gary J. Fosmire, Roland M. Leach

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Strontium has been reported to have beneficial effects on bone. Treatment of laying hens, which are susceptible to osteoporosis and bone fracture, with strontium increased DXA measurements of BMD and BMC and μCT measurements of bone volume and microarchitecture and improved the mechanical performance of whole bone, but had no effect on the estimated material properties of the bone tissue. Introduction: Strontium (Sr) has been reported to dissociate bone remodeling and have positive influences on bone formation. We supplemented the diet of laying hens, which are susceptible to osteoporosis and bone fracture, with Sr to study the capacity of the element to improve bone mechanical integrity and resistance to fracture. Materials and Methods: Increasing dosages of Sr (0, 3000, 4500, and 6000 ppm) were fed to 196 13-week-old pullets for 11 months. BMD and BMC, as measured by conventional and DXA methods, microarchitectural parameters derived from μCT, and structural and material properties as determined by three-point bending test, were studied. Calcium (Ca), phosphorus (P), and Sr levels in plasma and bone, as well as egg output, shell quality, and composition, were assessed. Results: Sr concentrations in plasma and bone increased in a dose-dependent manner without affecting Ca and P. Treatment with Sr increased BMD and BMC as measured by DXA, increased cortical and medullary bone volume, trabecular thickness, number, and surface, and improved whole bone ultimate load, but had no effect on the estimated material properties of diaphyseal bone. Sr also increased the ash content of eggshells and did not affect egg output and shell quality. Conclusions: Sr supplementation induced large positive effects on bone density, volume, and microarchitecture as measured by radiographic methods. Sr treatment also improved the structural strength of diaphyseal bone but had no effect on the estimated material properties of the bone tissue.

Original languageEnglish (US)
Pages (from-to)1696-1703
Number of pages8
JournalJournal of Bone and Mineral Research
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2006

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Strontium
Bone Density
Bone and Bones
Egg Shell
Bone Fractures
Osteoporosis
Calcium
Bone Remodeling
Osteogenesis
Phosphorus
Diet

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Shahnazari, Mohammad ; Sharkey, Neil ; Fosmire, Gary J. ; Leach, Roland M. / Effects of strontium on bone strength, density, volume, and microarchitecture in laying hens. In: Journal of Bone and Mineral Research. 2006 ; Vol. 21, No. 11. pp. 1696-1703.
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Effects of strontium on bone strength, density, volume, and microarchitecture in laying hens. / Shahnazari, Mohammad; Sharkey, Neil; Fosmire, Gary J.; Leach, Roland M.

In: Journal of Bone and Mineral Research, Vol. 21, No. 11, 01.11.2006, p. 1696-1703.

Research output: Contribution to journalArticle

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