Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults

Michael R. Flock, Ann C. Skulas-Ray, William S. Harris, Trent L. Gaugler, Jennifer Anne Fleming, Penny Margaret Kris-Etherton

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalProstaglandins, leukotrienes, and essential fatty acids
Volume91
Issue number4
DOIs
StatePublished - Oct 1 2014

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Docosahexaenoic Acids
Omega-3 Fatty Acids
Erythrocyte Membrane
Eicosapentaenoic Acid
Fatty Acids
Randomized Controlled Trials
Membranes
Interleukin-6
Blood
Erythrocytes
Young Adult
Cell membranes
Arachidonic Acid
Fish
Fishes
Anti-Inflammatory Agents
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

Cite this

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title = "Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults",
abstract = "The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.",
author = "Flock, {Michael R.} and Skulas-Ray, {Ann C.} and Harris, {William S.} and Gaugler, {Trent L.} and Fleming, {Jennifer Anne} and Kris-Etherton, {Penny Margaret}",
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AU - Harris, William S.

AU - Gaugler, Trent L.

AU - Fleming, Jennifer Anne

AU - Kris-Etherton, Penny Margaret

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