Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention

Zhe Hou, Joshua D. Lambert, Khew Voon Chin, Chung S. Yang

Research output: Contribution to journalReview article

127 Citations (Scopus)

Abstract

The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models by many investigators. The mechanisms of this inhibitory activity have also been investigated extensively, mostly in cell culture systems, but no clear conclusion can be reached concerning the cancer preventive mechanisms in vivo. In this article, we reviewed the possible mechanisms, which include the inhibition of specific protein kinase activities, blocking receptor-mediated functions, and inhibition of proteases. These events may lead to cell cycle regulation, growth inhibition, enhanced apoptosis, inhibition of angiogenesis, and inhibition of invasion and metastases. The possible complications of translating results obtained in cell culture studies to animals and humans are discussed. It is likely that multiple signal transduction pathways are involved in the inhibition of carcinogenesis by tea constituents. The relative importance of these pathways needs to be determined in vivo.

Original languageEnglish (US)
Pages (from-to)3-19
Number of pages17
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume555
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - Nov 2 2004

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Chemoprevention
Polyphenols
Tea
Signal Transduction
Carcinogenesis
Cell Culture Techniques
Neoplasms
Protein Kinases
Cell Cycle
Peptide Hydrolases
Animal Models
Research Personnel
Apoptosis
Neoplasm Metastasis
Growth

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

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abstract = "The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models by many investigators. The mechanisms of this inhibitory activity have also been investigated extensively, mostly in cell culture systems, but no clear conclusion can be reached concerning the cancer preventive mechanisms in vivo. In this article, we reviewed the possible mechanisms, which include the inhibition of specific protein kinase activities, blocking receptor-mediated functions, and inhibition of proteases. These events may lead to cell cycle regulation, growth inhibition, enhanced apoptosis, inhibition of angiogenesis, and inhibition of invasion and metastases. The possible complications of translating results obtained in cell culture studies to animals and humans are discussed. It is likely that multiple signal transduction pathways are involved in the inhibition of carcinogenesis by tea constituents. The relative importance of these pathways needs to be determined in vivo.",
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Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. / Hou, Zhe; Lambert, Joshua D.; Chin, Khew Voon; Yang, Chung S.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 555, No. 1-2 SPEC. ISS., 02.11.2004, p. 3-19.

Research output: Contribution to journalReview article

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AU - Hou, Zhe

AU - Lambert, Joshua D.

AU - Chin, Khew Voon

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