Effects of the ovarian cycle on sympathetic neural outflow during static exercise

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Abstract

We compared reflex responses to static handgrip at 30% maximal voluntary contraction (MVC) in 10 women (mean age 24.1 ± 1.7 yr) during two phases of their ovarian cycle: the menstrual phase (days 1-4) and the follicular phase (days 10-12). Changes in muscle sympathetic nerve activity (MSNA; microneurography) in response to static exercise were greater during the menstrual compared with follicular phase (phase effect P = 0.01). Levels of estrogen were less during the menstrual phase (75 ± 5.5 vs. 116 ± 9.6 pg/ml, days 1-4 vs. days 10-12; P = 0.002). Generated tension did not explain differences in MSNA responses (MVC: 29.3 ± 1.3 vs. 28.2 ± 1.5 kg, days 1-4 vs. days 10-12; P = 0.13). In a group of experiments with the use of 31p- NMR spectroscopy, no phase effect was observed for H+ and H2PO4/- concentrations (n = 5). During an ischemic rhythmic handgrip paradigm (20% MVC), a phase effect was not observed for MSNA or H+ or H2PO4/- concentrations, suggesting that blood flow was necessary for the expression of the cycle-related effect. The present studies suggest that, during static handgrip exercise, MSNA is increased during the menstrual compared with the follicular phase of the ovarian cycle.

Original languageEnglish (US)
Pages (from-to)2075-2081
Number of pages7
JournalJournal of Applied Physiology
Volume85
Issue number6
DOIs
StatePublished - Jan 1 1998

Fingerprint

Follicular Phase
Menstrual Cycle
Exercise
Reflex
Estrogens
Magnetic Resonance Spectroscopy
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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title = "Effects of the ovarian cycle on sympathetic neural outflow during static exercise",
abstract = "We compared reflex responses to static handgrip at 30{\%} maximal voluntary contraction (MVC) in 10 women (mean age 24.1 ± 1.7 yr) during two phases of their ovarian cycle: the menstrual phase (days 1-4) and the follicular phase (days 10-12). Changes in muscle sympathetic nerve activity (MSNA; microneurography) in response to static exercise were greater during the menstrual compared with follicular phase (phase effect P = 0.01). Levels of estrogen were less during the menstrual phase (75 ± 5.5 vs. 116 ± 9.6 pg/ml, days 1-4 vs. days 10-12; P = 0.002). Generated tension did not explain differences in MSNA responses (MVC: 29.3 ± 1.3 vs. 28.2 ± 1.5 kg, days 1-4 vs. days 10-12; P = 0.13). In a group of experiments with the use of 31p- NMR spectroscopy, no phase effect was observed for H+ and H2PO4/- concentrations (n = 5). During an ischemic rhythmic handgrip paradigm (20{\%} MVC), a phase effect was not observed for MSNA or H+ or H2PO4/- concentrations, suggesting that blood flow was necessary for the expression of the cycle-related effect. The present studies suggest that, during static handgrip exercise, MSNA is increased during the menstrual compared with the follicular phase of the ovarian cycle.",
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Effects of the ovarian cycle on sympathetic neural outflow during static exercise. / Ettinger, Steven; Silber, David; Gray, Kristen S.; Smith, Michael B.; Yang, Qing; Kunselman, Allen; Sinoway, Lawrence.

In: Journal of Applied Physiology, Vol. 85, No. 6, 01.01.1998, p. 2075-2081.

Research output: Contribution to journalArticle

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AU - Ettinger, Steven

AU - Silber, David

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AU - Yang, Qing

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AU - Sinoway, Lawrence

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