Effects of transmural pressure on brachial artery mean blood velocity dynamics in humans

Mary E.J. Lott, Michael D. Herr, Lawrence I. Sinoway

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of changes in transmural pressure on brachial artery mean blood velocity (MBV) were examined in humans. Transmural pressure was altered by using a specially designed pressure tank that raised or lowered forearm pressure by 50 mmHg within 0.2 s. Brachial MBV was measured with Doppler directly above the site of forearm pressure change. Pressure changes were evoked during resting conditions and after a 5-s handgrip contraction at 25% maximal voluntary contraction. The handgrip protocol selected was sufficiently vigorous to limit flow and sufficiently brief to prevent autonomic engagement. Changes in transmural pressure evoked directionally similar changes in MBV within 2 s. This was followed by large and rapid adjustments [-2.14 ± 0.24 cm/s (vasoconstriction) during negative pressure and +2.14 ± 0.45 cm/s (vasodilatation) during positive pressure]. These adjustments served to return MBV to resting levels. This regulatory influence remained operative after 5-s static handgrip contractions. Of note, changes in transmural pressure were capable of altering the timing of the peak MBV response (5 ± 0, 2 ± 0, 6 ± 1 s ambient, negative, and positive pressure, respectively) as well as the speed of MBV adjustment (-2.03 ± 0.18, -2.48 ± 0.15, -0.84 ± 0.19 cm.s-1.s-1 ambient, negative, and positive pressure, respectively) after handgrip contractions. Vascular responses, seen with changes in transmural pressure, provide evidence that the myogenic response is normally operative in the limb circulation of humans.

Original languageEnglish (US)
Pages (from-to)2137-2146
Number of pages10
JournalJournal of applied physiology
Volume93
Issue number6
DOIs
StatePublished - Dec 2002

Fingerprint

Brachial Artery
Pressure
Forearm
Vasoconstriction
Vasodilation
Blood Vessels
Arm
Extremities

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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title = "Effects of transmural pressure on brachial artery mean blood velocity dynamics in humans",
abstract = "The effects of changes in transmural pressure on brachial artery mean blood velocity (MBV) were examined in humans. Transmural pressure was altered by using a specially designed pressure tank that raised or lowered forearm pressure by 50 mmHg within 0.2 s. Brachial MBV was measured with Doppler directly above the site of forearm pressure change. Pressure changes were evoked during resting conditions and after a 5-s handgrip contraction at 25{\%} maximal voluntary contraction. The handgrip protocol selected was sufficiently vigorous to limit flow and sufficiently brief to prevent autonomic engagement. Changes in transmural pressure evoked directionally similar changes in MBV within 2 s. This was followed by large and rapid adjustments [-2.14 ± 0.24 cm/s (vasoconstriction) during negative pressure and +2.14 ± 0.45 cm/s (vasodilatation) during positive pressure]. These adjustments served to return MBV to resting levels. This regulatory influence remained operative after 5-s static handgrip contractions. Of note, changes in transmural pressure were capable of altering the timing of the peak MBV response (5 ± 0, 2 ± 0, 6 ± 1 s ambient, negative, and positive pressure, respectively) as well as the speed of MBV adjustment (-2.03 ± 0.18, -2.48 ± 0.15, -0.84 ± 0.19 cm.s-1.s-1 ambient, negative, and positive pressure, respectively) after handgrip contractions. Vascular responses, seen with changes in transmural pressure, provide evidence that the myogenic response is normally operative in the limb circulation of humans.",
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Effects of transmural pressure on brachial artery mean blood velocity dynamics in humans. / Lott, Mary E.J.; Herr, Michael D.; Sinoway, Lawrence I.

In: Journal of applied physiology, Vol. 93, No. 6, 12.2002, p. 2137-2146.

Research output: Contribution to journalArticle

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