Efficacy of Intrapleural Tissue-type Plasminogen Activator in the Treatment of Loculated Parapneumonic Effusions

Darryl A. Zuckerman, Michael F. Reed, John A. Howington, Jonathan S. Moulton

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose: To assess the feasibility and effectiveness of intrapleural recombinant tissue-type plasminogen activator (r-tPA) in the treatment of loculated parapneumonic effusions (PPEs). Materials and Methods: A single-arm prospective study of 25 consecutive patients with loculated PPEs was analyzed. All patients received 6-mg doses of intrapleural r-tPA on a defined schedule via a thoracostomy tube. The volume of output from the tubes was recorded and analysis of the fluid composition performed. Follow-up was both clinical and radiographic, with all patients undergoing pre- and postprocedural computed tomography. Results: Eighteen of the 25 patients (72%) required no additional intervention and had a complete clinical and radiographic response with the fibrinolytic therapy. Seven patients (28%) were treated with video-assisted thoracoscopic surgery, but no patient required thoracotomy for total decortication. There were no hemorrhagic complications. Conclusions: Intrapleural r-tPA is effective in the treatment of loculated PPEs. It can be performed safely and in some patients may avoid the need for additional surgical intervention.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
JournalJournal of Vascular and Interventional Radiology
Volume20
Issue number8
DOIs
StatePublished - Aug 1 2009

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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