Efficient methodology for alkylation of vinylnitroso compounds with carbon nucleophiles

Puhui Li, Max M. Majireck, Jason A. Witek, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A diverse array of nitrosoalkenes derived from both acyclic and cyclic ketones, as well as aldehydes, via the Denmark protocol using α-chloro-O-TBS-oximes can be trapped efficiently in situ by a wide variety of potassium ester enolates to afford conjugate addition products in good yields.

Original languageEnglish (US)
Pages (from-to)2032-2035
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number15
DOIs
StatePublished - Apr 14 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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