Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration

Qing Li, Limei Li, Mali Yu, Meng Zheng, Yao Li, Jian Yang, Min Dai, Lianmei Zhong, Lin Sun, Di Lu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The extracellular matrix provides cells with a support structure and an attachment site in actual substrate. Its biochemical and surface properties play an important role in and have significant impact on cell attachment, proliferation, migration, differentiation, and gene expression. Leveraging the hydrophilicity and neuroprotective of gastrodin, a gastrodin/polyurethane (PU) elastomer was developed utilizing in situ polymerization and salt-leaching methods. The results showed that gastrodin/PU film had a good flexibility and supporting strength, as well as hydrophilicity. Thus film possessed highly surface area, interconnected porous structure with a pore size (10~60 μm) for cell attachment, and could provide surface cues to augment neurite extension. For PC12 cells cultured within the films, especially the 5gastrodin/PU group, presented a progressive increase with time, coupled with the upregulation of brain-derived neurotrophic factor and glial cell derived neurotrophic factor expression. This is the first report on the construction of a gastrodin/PU porous film, and the results reveal its promise as a scaffold material for neural tissue engineering.

Original languageEnglish (US)
Pages (from-to)1713-1725
Number of pages13
JournalJournal of Biomedical Materials Research - Part A
Volume108
Issue number8
DOIs
StatePublished - Aug 1 2020

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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