Electrical stimulation of the horizontal limb of the diagonal band of broca modulates population EPSPs in piriform cortex

Christiane Linster, Bradley P. Wyble, Michael E. Hasselmo

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Electrical stimulation of the horizontal limb of the diagonal band of Broca (HDB) was coupled with recording of evoked potentials in the piriform cortex. Stimulation of the HDB caused an enhancement of the late, disynaptic component of the evoked potential elicited by stimulation of the lateral olfactory tract but caused a suppression of the synaptic potential elicited by stimulation of the posterior piriform cortex. The muscarinic antagonist scopolamine blocked both effects of HDB stimulation. The enhancement of disynaptic potentials could be due to cholinergic depolarization of pyramidal cells, whereas the suppression of potentials evoked by posterior piriform stimulation could be due to presynaptic inhibition of intrinsic fiber synaptic transmission by acetylcholine.

Original languageEnglish (US)
Pages (from-to)2737-2742
Number of pages6
JournalJournal of neurophysiology
Volume81
Issue number6
DOIs
StatePublished - Jan 1 1999

Fingerprint

Diagonal Band of Broca
Excitatory Postsynaptic Potentials
Evoked Potentials
Electric Stimulation
Extremities
Population
Synaptic Potentials
Muscarinic Antagonists
Scopolamine Hydrobromide
Pyramidal Cells
Olfactory Bulb
Synaptic Transmission
Cholinergic Agents
Acetylcholine
Piriform Cortex

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

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abstract = "Electrical stimulation of the horizontal limb of the diagonal band of Broca (HDB) was coupled with recording of evoked potentials in the piriform cortex. Stimulation of the HDB caused an enhancement of the late, disynaptic component of the evoked potential elicited by stimulation of the lateral olfactory tract but caused a suppression of the synaptic potential elicited by stimulation of the posterior piriform cortex. The muscarinic antagonist scopolamine blocked both effects of HDB stimulation. The enhancement of disynaptic potentials could be due to cholinergic depolarization of pyramidal cells, whereas the suppression of potentials evoked by posterior piriform stimulation could be due to presynaptic inhibition of intrinsic fiber synaptic transmission by acetylcholine.",
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Electrical stimulation of the horizontal limb of the diagonal band of broca modulates population EPSPs in piriform cortex. / Linster, Christiane; Wyble, Bradley P.; Hasselmo, Michael E.

In: Journal of neurophysiology, Vol. 81, No. 6, 01.01.1999, p. 2737-2742.

Research output: Contribution to journalArticle

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