Electrochemical Analysis in Picoliter Microvials

Rose A. Clark, Paula Beyer Hietpas, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


Lithographically fabricated templates have been used to imprint picoliter to femtoliter microvials in polystyrene. The clear microvials produced in conjunction with a transmission optical microscope and micromanipulators make it possible to handle volumes as small as 1 pL. Voltammetry has been carried out in these well-defined microenvironments with restriction of reagents near the electrode surface. Ferrocenecarboxylic acid has been utilized to characterize the electrochemical response in these ultrasmall volumes. Sigmoidal voltammograms (0.4-2 V/s) are obtained for vial sizes down to 1 pL.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalAnalytical Chemistry
Issue number2
StatePublished - 1997

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry


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