Electron-Acceptor and Electron-Donor Chromatographic Stationary Phases for the Reversed-Phase Liquid Chromatographic Separation and Isomer Identification of Polychlorinated Dibenzo-p-dioxins

Kazuhiro Kimata, Ken Hosoya, Takeo Araki, Nobuo Tanaka, Elizabeth R. Barnhart, Louis R. Alexander, Sarath Sirimanne, Patriciac C. McClure, James Grainger, Donald G. Patterson

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26 Scopus citations

Abstract

To assess the impact of environmental toxicants on human health, researchers routinely use GC/MS, and the compounds they use for analytical reference standards must be synthesized, purified, and characterized. Reversed-phase HPLC separation and structure identification of polychlorinated dibenzo-p-dioxin (PCDD) isomers (potentially hazardous environmental contaminants) in synthesis reaction mixtures were accomplished by taking advantage of the different retention mechanisms at work on four different stationary phases bonded to silica gel. Hydrophobic, charge-transfer, and dipole-dipole interactions characterize the analyte elution orders of the positional isomers of PCDDs from columns packed with C18, pyrenylethyl, (nitrophenyl)ethyl, and (nitrophenoxy)-propyl stationary phases.

Original languageEnglish (US)
Pages (from-to)2502-2509
Number of pages8
JournalAnalytical chemistry
Volume65
Issue number18
DOIs
StatePublished - Sep 1 1993

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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    Kimata, K., Hosoya, K., Araki, T., Tanaka, N., Barnhart, E. R., Alexander, L. R., Sirimanne, S., McClure, P. C., Grainger, J., & Patterson, D. G. (1993). Electron-Acceptor and Electron-Donor Chromatographic Stationary Phases for the Reversed-Phase Liquid Chromatographic Separation and Isomer Identification of Polychlorinated Dibenzo-p-dioxins. Analytical chemistry, 65(18), 2502-2509. https://doi.org/10.1021/ac00066a018