Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway

Wolfgang Quitschke, Andrew Francis, Nisson Schechter

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Proteins in the goldfish retinotectal pathway were analyzed by 2-D gel electrophoresis, under conditions of optic nerve crush or eye removal. A specific cluster of proteins was detected, consisting of 4 components, all of which are highly concentrated in the intact optic nerve. Two components were not detectable in non-visual areas of the goldfish brain. The total cluster was diminished by about 80% in the denervated optic tectum, and its level was restored during optic nerve regeneration. These data were interpreted as evidence for visual system-specific proteins in the goldfish retinotectal pathway.

Original languageEnglish (US)
Pages (from-to)347-360
Number of pages14
JournalBrain research
Volume201
Issue number2
DOIs
StatePublished - Nov 17 1980

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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