Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway

Wolfgang Quitschke, Andrew Francis, Nisson Schechter

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Proteins in the goldfish retinotectal pathway were analyzed by 2-D gel electrophoresis, under conditions of optic nerve crush or eye removal. A specific cluster of proteins was detected, consisting of 4 components, all of which are highly concentrated in the intact optic nerve. Two components were not detectable in non-visual areas of the goldfish brain. The total cluster was diminished by about 80% in the denervated optic tectum, and its level was restored during optic nerve regeneration. These data were interpreted as evidence for visual system-specific proteins in the goldfish retinotectal pathway.

Original languageEnglish (US)
Pages (from-to)347-360
Number of pages14
JournalBrain research
Volume201
Issue number2
DOIs
StatePublished - Nov 17 1980

Fingerprint

Goldfish
Optic Nerve
Nerve Crush
Nerve Regeneration
Proteins
Superior Colliculi
Electrophoresis, Gel, Two-Dimensional
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Quitschke, Wolfgang ; Francis, Andrew ; Schechter, Nisson. / Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway. In: Brain research. 1980 ; Vol. 201, No. 2. pp. 347-360.
@article{e59ba2c286254db2834e1cfaf928adf7,
title = "Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway",
abstract = "Proteins in the goldfish retinotectal pathway were analyzed by 2-D gel electrophoresis, under conditions of optic nerve crush or eye removal. A specific cluster of proteins was detected, consisting of 4 components, all of which are highly concentrated in the intact optic nerve. Two components were not detectable in non-visual areas of the goldfish brain. The total cluster was diminished by about 80{\%} in the denervated optic tectum, and its level was restored during optic nerve regeneration. These data were interpreted as evidence for visual system-specific proteins in the goldfish retinotectal pathway.",
author = "Wolfgang Quitschke and Andrew Francis and Nisson Schechter",
year = "1980",
month = "11",
day = "17",
doi = "10.1016/0006-8993(80)91039-2",
language = "English (US)",
volume = "201",
pages = "347--360",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway. / Quitschke, Wolfgang; Francis, Andrew; Schechter, Nisson.

In: Brain research, Vol. 201, No. 2, 17.11.1980, p. 347-360.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway

AU - Quitschke, Wolfgang

AU - Francis, Andrew

AU - Schechter, Nisson

PY - 1980/11/17

Y1 - 1980/11/17

N2 - Proteins in the goldfish retinotectal pathway were analyzed by 2-D gel electrophoresis, under conditions of optic nerve crush or eye removal. A specific cluster of proteins was detected, consisting of 4 components, all of which are highly concentrated in the intact optic nerve. Two components were not detectable in non-visual areas of the goldfish brain. The total cluster was diminished by about 80% in the denervated optic tectum, and its level was restored during optic nerve regeneration. These data were interpreted as evidence for visual system-specific proteins in the goldfish retinotectal pathway.

AB - Proteins in the goldfish retinotectal pathway were analyzed by 2-D gel electrophoresis, under conditions of optic nerve crush or eye removal. A specific cluster of proteins was detected, consisting of 4 components, all of which are highly concentrated in the intact optic nerve. Two components were not detectable in non-visual areas of the goldfish brain. The total cluster was diminished by about 80% in the denervated optic tectum, and its level was restored during optic nerve regeneration. These data were interpreted as evidence for visual system-specific proteins in the goldfish retinotectal pathway.

UR - http://www.scopus.com/inward/record.url?scp=0019199310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019199310&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(80)91039-2

DO - 10.1016/0006-8993(80)91039-2

M3 - Article

C2 - 7417846

AN - SCOPUS:0019199310

VL - 201

SP - 347

EP - 360

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -