Electrophysiology of phosphodiesterase inhibitors

Gerald Naccarelli, Richard A. Goldstein

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Phosphodiesterase inhibitors appear to uniformly enhance atrioventricular node conduction, although milrinone seems to have the least effect. Except for digoxin, this effect on atrioventricular node conduction is similar to that noted with other inotropic agents. Other electrophysiologic effects vary among patients, with enoximone being more theophylline-like in response. Because none of these drugs do not have an adverse effect on His-Purkinje conduction, they are safe to use in patients with intraventricular conduction disturbances. Significant proarrhythmia is uncommon, but can occur. The mechanisms causing these electrophysiologic changes are not well defined, but the changes may occur because of increased concentrations of cytosol cyclic adenosine monophosphate secondary to Phosphodiesterase inhibition, increased cytosol calcium levels secondary to increased cyclic adenosine monophosphate, or reflex adrenergic stimulation secondary to the peripheral vasodilating effects of these drugs.

Original languageEnglish (US)
JournalThe American Journal of Cardiology
Volume63
Issue number2
DOIs
StatePublished - Jan 3 1989

Fingerprint

Atrioventricular Node
Phosphodiesterase Inhibitors
Electrophysiology
Cyclic AMP
Cytosol
Enoximone
Milrinone
Digoxin
Phosphoric Diester Hydrolases
Theophylline
Pharmaceutical Preparations
Adrenergic Agents
Reflex
Calcium
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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Electrophysiology of phosphodiesterase inhibitors. / Naccarelli, Gerald; Goldstein, Richard A.

In: The American Journal of Cardiology, Vol. 63, No. 2, 03.01.1989.

Research output: Contribution to journalArticle

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