TY - JOUR
T1 - Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP)
T2 - A case report
AU - Birchall, Courtney
AU - Prentice, Danielle
AU - Pauli, Jaimey
PY - 2020/4
Y1 - 2020/4
N2 - Background: Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications. Case: A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormalities in the setting of newly diagnosed hepatitis C and severe ICP on repeat SBA testing. Conclusion: This case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals.
AB - Background: Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications. Case: A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormalities in the setting of newly diagnosed hepatitis C and severe ICP on repeat SBA testing. Conclusion: This case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals.
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U2 - 10.1016/j.crwh.2020.e00178
DO - 10.1016/j.crwh.2020.e00178
M3 - Article
C2 - 32055455
AN - SCOPUS:85078856944
VL - 26
JO - Case Reports in Women's Health
JF - Case Reports in Women's Health
SN - 2214-9112
M1 - e00178
ER -