Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report

Courtney Birchall, Danielle Prentice, Jaimey Pauli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications. Case: A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormalities in the setting of newly diagnosed hepatitis C and severe ICP on repeat SBA testing. Conclusion: This case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals.

Original languageEnglish (US)
Article numbere00178
JournalCase Reports in Women's Health
Volume26
DOIs
StatePublished - Apr 2020

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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