Elevated serum ige, eosinophilia, and lung function in rubber workers

Rebecca Bascom, Michael E. Baser, Richard J. Thomas, John F. Fisher, William N. Yang, John H. Baker, Rebecca Bascom, Michael E. Baser, Richard J. Thomas, John F. Fisher, William N. Yang, John H. Baker

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We previously reported an outbreak of acute respiratory illness associated with eosinophilia in a group of rubber workers who performed a thermoinjection process in which synthetic rubber was heated and then injected onto metal molds. This study was conducted to determine if persistent respiratory health effects were associated with this work area and to explore the possible allergic etiology of this syndrome. A survey was performed 1 mo after a major improvement in area ventilation and consisted of baseline, cross-shift, and cross-week spirometry; diffusing capacity; serum immunoglobulin E (IgE), total eosinophil count; and skin patch testing. Baseline lung function, cross-shift, and cross-week spirometry were not significantly worse in the exposed group as compared to the control group. However, either eosinophilia (> 450/mm3) or elevated serum IgE (> 470 ng/ml) were present in 44% of exposed workers vs. 11% of the control group (p =.003). Nine months later, neither eosinophilia nor elevated IgE were associated with employment in this work area. We conclude that employment in the thermoinjection process was associated with eosinophilia and elevated IgE, which suggests sensitization to one of the components of the rubber, although no effect on pulmonary function could be demonstrated.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalArchives of Environmental Health
Volume45
Issue number1
DOIs
StatePublished - Jan 1 1990

Fingerprint

Rubber
Eosinophilia
rubber
Immunoglobulin E
serum
Lung
Spirometry
Serum
etiology
Elastomers
Control Groups
ventilation
skin
Molds
Eosinophils
Ventilation
Disease Outbreaks
Skin
Fungi
Metals

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Bascom, R., Baser, M. E., Thomas, R. J., Fisher, J. F., Yang, W. N., Baker, J. H., ... Baker, J. H. (1990). Elevated serum ige, eosinophilia, and lung function in rubber workers. Archives of Environmental Health, 45(1), 15-19. https://doi.org/10.1080/00039896.1990.9935918
Bascom, Rebecca ; Baser, Michael E. ; Thomas, Richard J. ; Fisher, John F. ; Yang, William N. ; Baker, John H. ; Bascom, Rebecca ; Baser, Michael E. ; Thomas, Richard J. ; Fisher, John F. ; Yang, William N. ; Baker, John H. / Elevated serum ige, eosinophilia, and lung function in rubber workers. In: Archives of Environmental Health. 1990 ; Vol. 45, No. 1. pp. 15-19.
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Bascom, R, Baser, ME, Thomas, RJ, Fisher, JF, Yang, WN, Baker, JH, Bascom, R, Baser, ME, Thomas, RJ, Fisher, JF, Yang, WN & Baker, JH 1990, 'Elevated serum ige, eosinophilia, and lung function in rubber workers', Archives of Environmental Health, vol. 45, no. 1, pp. 15-19. https://doi.org/10.1080/00039896.1990.9935918

Elevated serum ige, eosinophilia, and lung function in rubber workers. / Bascom, Rebecca; Baser, Michael E.; Thomas, Richard J.; Fisher, John F.; Yang, William N.; Baker, John H.; Bascom, Rebecca; Baser, Michael E.; Thomas, Richard J.; Fisher, John F.; Yang, William N.; Baker, John H.

In: Archives of Environmental Health, Vol. 45, No. 1, 01.01.1990, p. 15-19.

Research output: Contribution to journalArticle

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