Emergence of fluoroquinolone-resistant tuberculosis in New York City

E. A. Sullivan; L. Palumbo; A. Ebrahimzadeh; T. R. Frieden; E. A. Sullivan; T. R. Frieden; B. N. Kreiswirth; Vivek Kapur; J. M. Musser

doi:10.1016/S0140-6736(95)90980-X

Emergence of fluoroquinolone-resistant tuberculosis in New York City

E. A. Sullivan, L. Palumbo, A. Ebrahimzadeh, T. R. Frieden, E. A. Sullivan, T. R. Frieden, B. N. Kreiswirth, Vivek Kapur, J. M. Musser

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

Original language	English (US)
Pages (from-to)	1148-1150
Number of pages	3
Journal	The Lancet
Volume	345
Issue number	8958
DOIs	https://doi.org/10.1016/S0140-6736(95)90980-X
State	Published - May 6 1995

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/S0140-6736(95)90980-X

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title = "Emergence of fluoroquinolone-resistant tuberculosis in New York City",

abstract = "22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.",

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AU - Sullivan, E. A.

AU - Palumbo, L.

AU - Ebrahimzadeh, A.

AU - Frieden, T. R.

AU - Sullivan, E. A.

AU - Frieden, T. R.

AU - Kreiswirth, B. N.

AU - Kapur, Vivek

AU - Musser, J. M.

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AB - 22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

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