Emergence of fluoroquinolone-resistant tuberculosis in New York City

E. A. Sullivan; L. Palumbo; A. Ebrahimzadeh; T. R. Frieden; E. A. Sullivan; T. R. Frieden; B. N. Kreiswirth; V. Kapur; J. M. Musser

doi:10.1016/S0140-6736(95)90980-X

Emergence of fluoroquinolone-resistant tuberculosis in New York City

E. A. Sullivan, L. Palumbo, A. Ebrahimzadeh, T. R. Frieden, E. A. Sullivan, T. R. Frieden, B. N. Kreiswirth, V. Kapur, J. M. Musser

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116 Scopus citations

Abstract

22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

Original language	English (US)
Pages (from-to)	1148-1150
Number of pages	3
Journal	The Lancet
Volume	345
Issue number	8958
DOIs	https://doi.org/10.1016/S0140-6736(95)90980-X
State	Published - May 6 1995

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/S0140-6736(95)90980-X

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title = "Emergence of fluoroquinolone-resistant tuberculosis in New York City",

abstract = "22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.",

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AU - Sullivan, E. A.

AU - Palumbo, L.

AU - Ebrahimzadeh, A.

AU - Frieden, T. R.

AU - Sullivan, E. A.

AU - Frieden, T. R.

AU - Kreiswirth, B. N.

AU - Kapur, V.

AU - Musser, J. M.

PY - 1995/5/6

Y1 - 1995/5/6

N2 - 22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

AB - 22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

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Emergence of fluoroquinolone-resistant tuberculosis in New York City

Abstract

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