Abstract
22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.
Original language | English (US) |
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Pages (from-to) | 1148-1150 |
Number of pages | 3 |
Journal | The Lancet |
Volume | 345 |
Issue number | 8958 |
DOIs | |
State | Published - May 6 1995 |
All Science Journal Classification (ASJC) codes
- Medicine(all)