Emerging perspectives in store-operated Ca2+ entry: Roles of Orai, Stim and TRP

Jeremy T. Smyth, Wayne I. DeHaven, Bertina F. Jones, Jason C. Mercer, Mohamed Trebak, Guillermo Vazquez, James W. Putney

Research output: Contribution to journalReview articlepeer-review

190 Scopus citations


Depletion of intracellular Ca2+ stores induces Ca2+ influx across the plasma membrane through store-operated channels (SOCs). This store-operated Ca2+ influx is important for the replenishment of the Ca2+ stores, and is also involved in many signaling processes by virtue of the ability of intracellular Ca2+ to act as a second messenger. For many years, the molecular identities of particular SOCs, as well as the signaling mechanisms by which these channels are activated, have been elusive. Recently, however, the mammalian proteins STIM1 and Orai1 were shown to be necessary for the activation of store-operated Ca2+ entry in a variety of mammalian cells. Here we present molecular, pharmacological, and electrophysiological properties of SOCs, with particular focus on the roles that STIM1 and Orai1 may play in the signaling processes that regulate various pathways of store-operated entry.

Original languageEnglish (US)
Pages (from-to)1147-1160
Number of pages14
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number11
StatePublished - Nov 2006

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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