Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents

Anna J. Smith, Lily K. Abbott, Stephen F. Martin

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams In high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronatlon

Original languageEnglish (US)
Pages (from-to)4200-4203
Number of pages4
JournalOrganic Letters
Volume11
Issue number18
DOIs
StatePublished - Sep 17 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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