Enantioselective reduction of β-keto esters

Douglass F. Taber, Lee J. Silverberg

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP-Ru catalyst is reported. Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP·Ru catalyst is reported.

Original languageEnglish (US)
Pages (from-to)4227-4230
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number34
DOIs
StatePublished - 1991

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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