Enantioselective reduction of β-keto esters

Douglass F. Taber, Lee J. Silverberg

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP-Ru catalyst is reported. Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP·Ru catalyst is reported.

Original languageEnglish (US)
Pages (from-to)4227-4230
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number34
DOIs
StatePublished - 1991

Fingerprint

Esters
Catalysts
2-naphthol BINAP

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Taber, Douglass F. ; Silverberg, Lee J. / Enantioselective reduction of β-keto esters. In: Tetrahedron Letters. 1991 ; Vol. 32, No. 34. pp. 4227-4230.
@article{1f495cb7636e4b6a9dbe7a6cab9d242c,
title = "Enantioselective reduction of β-keto esters",
abstract = "Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP-Ru catalyst is reported. Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP·Ru catalyst is reported.",
author = "Taber, {Douglass F.} and Silverberg, {Lee J.}",
year = "1991",
doi = "10.1016/S0040-4039(00)92134-8",
language = "English (US)",
volume = "32",
pages = "4227--4230",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "34",

}

Enantioselective reduction of β-keto esters. / Taber, Douglass F.; Silverberg, Lee J.

In: Tetrahedron Letters, Vol. 32, No. 34, 1991, p. 4227-4230.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enantioselective reduction of β-keto esters

AU - Taber, Douglass F.

AU - Silverberg, Lee J.

PY - 1991

Y1 - 1991

N2 - Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP-Ru catalyst is reported. Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP·Ru catalyst is reported.

AB - Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP-Ru catalyst is reported. Highly enantioselective reduction of β-keto esters with BINAP-Ru catalyst can be effected at 50 psig H2 and 80°, using a Parr shaker. A simplified preparation of the BINAP·Ru catalyst is reported.

UR - http://www.scopus.com/inward/record.url?scp=0025769026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025769026&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)92134-8

DO - 10.1016/S0040-4039(00)92134-8

M3 - Article

AN - SCOPUS:0025769026

VL - 32

SP - 4227

EP - 4230

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 34

ER -