Encapsulation and permeability characteristics of plasma polymerized hollow particles.

Anaram Shahravan, Themis Matsoukas

Research output: Contribution to journalArticle

Abstract

In this protocol, core-shell nanostructures are synthesized by plasma enhanced chemical vapor deposition. We produce an amorphous barrier by plasma polymerization of isopropanol on various solid substrates, including silica and potassium chloride. This versatile technique is used to treat nanoparticles and nanopowders with sizes ranging from 37 nm to 1 micron, by depositing films whose thickness can be anywhere from 1 nm to upwards of 100 nm. Dissolution of the core allows us to study the rate of permeation through the film. In these experiments, we determine the diffusion coefficient of KCl through the barrier film by coating KCL nanocrystals and subsequently monitoring the ionic conductivity of the coated particles suspended in water. The primary interest in this process is the encapsulation and delayed release of solutes. The thickness of the shell is one of the independent variables by which we control the rate of release. It has a strong effect on the rate of release, which increases from a six-hour release (shell thickness is 20 nm) to a long-term release over 30 days (shell thickness is 95 nm). The release profile shows a characteristic behavior: a fast release (35% of the final materials) during the first five minutes after the beginning of the dissolution, and a slower release till all of the core materials come out.

Original languageEnglish (US)
JournalJournal of Visualized Experiments
Issue number66
StatePublished - 2012

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Encapsulation
Nanoparticles
Permeability
Dissolution
Plasmas
Plasma polymerization
Potassium Chloride
2-Propanol
Nanostructures
Ionic conductivity
Plasma enhanced chemical vapor deposition
Permeation
Polymerization
Silicon Dioxide
Nanocrystals
Film thickness
Potassium
Silica
Coatings
Water

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "In this protocol, core-shell nanostructures are synthesized by plasma enhanced chemical vapor deposition. We produce an amorphous barrier by plasma polymerization of isopropanol on various solid substrates, including silica and potassium chloride. This versatile technique is used to treat nanoparticles and nanopowders with sizes ranging from 37 nm to 1 micron, by depositing films whose thickness can be anywhere from 1 nm to upwards of 100 nm. Dissolution of the core allows us to study the rate of permeation through the film. In these experiments, we determine the diffusion coefficient of KCl through the barrier film by coating KCL nanocrystals and subsequently monitoring the ionic conductivity of the coated particles suspended in water. The primary interest in this process is the encapsulation and delayed release of solutes. The thickness of the shell is one of the independent variables by which we control the rate of release. It has a strong effect on the rate of release, which increases from a six-hour release (shell thickness is 20 nm) to a long-term release over 30 days (shell thickness is 95 nm). The release profile shows a characteristic behavior: a fast release (35{\%} of the final materials) during the first five minutes after the beginning of the dissolution, and a slower release till all of the core materials come out.",
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Encapsulation and permeability characteristics of plasma polymerized hollow particles. / Shahravan, Anaram; Matsoukas, Themis.

In: Journal of Visualized Experiments, No. 66, 2012.

Research output: Contribution to journalArticle

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AU - Matsoukas, Themis

PY - 2012

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