Endogenous CCK in the control of gastric emptying of glucose and maltose

Timothy H. Moran, Douglas Field, Susan Knipp, Timothy S. Carrigan, Gary J. Schwartz

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalPeptides
Volume18
Issue number4
DOIs
StatePublished - Jul 11 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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