Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon

Joshua Kellogg, Huzefa A. Raja

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Endolichenic fungi are diverse groups of predominantly filamentous fungi that reside asymptomatically in the interior of lichen thalli. Natural products from endolichenic fungi, isolated from a variety of different lichen species, have been attracting increased attention for their potential to produce bioactive metabolites possessing new structures and representing different structural classes. This is evident from the steady increase of publications devoted to endolichenic fungal metabolites over the past decade, since the first report of endolichenic secondary metabolites. The bioactive metabolites produced by endolichenic fungi originate from multiple biosynthetic pathways and occupy different chemical structure classes, including steroids, quinones, terpenoids, peptides, xanthones, sulfur-containing chromenones, etc. Endolichenic fungal metabolites possess a diverse array of bioactivities, such as anticancer, antiviral, antibacterial, antifungal, and anti-Alzheimer’s disease. This review provides the first thorough assessment of endolichenic fungi, their biodiversity, secondary metabolites, and associated bioactivity. This review will highlight the bioactive metabolites reported in recent years from endolichenic fungi, as well as discussing the potential of these symbiotic fungi as sources of new, diverse natural products with varying bioactivities.

Original languageEnglish (US)
Pages (from-to)271-293
Number of pages23
JournalPhytochemistry Reviews
Volume16
Issue number2
DOIs
StatePublished - Apr 1 2017

Fingerprint

secondary metabolites
Fungi
fungi
metabolites
Lichens
Biological Products
lichens
Xanthones
xanthones
Quinones
Biodiversity
Biosynthetic Pathways
Terpenes
Alzheimer disease
quinones
thallus
Sulfur
chemical structure
terpenoids
steroids

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Plant Science

Cite this

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Endolichenic fungi : a new source of rich bioactive secondary metabolites on the horizon. / Kellogg, Joshua; Raja, Huzefa A.

In: Phytochemistry Reviews, Vol. 16, No. 2, 01.04.2017, p. 271-293.

Research output: Contribution to journalReview article

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