Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss

Margaret C.P. Ress, Anne B.M. Anderson, Laurence M. Demers, A. C. Turnbull

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Endometria and myometria were collected at hysterectomy from 42 women with measured menstrual blood loss. Specimens were obtained throughout the menstrual cycle [menstrual (n = 11), follicular (n = 9), early luteal (n = 6), midluteal (n = 9), and late luteal (n = 7)]. In vitro endometrial and myometrial release of prostaglandin F (PGF), PGE2, and 6-keto-PGF were examined using a superfusiontechnique. In the endometrium, the principal PG produced was PGF, while in th myometrium, it was 6-keto-PGFla−. Cyclical changes in PG release were found only inthe endometrium, with an increase toward the end of the menstrual cycle and during menstruation. No significant correlation was found between menstrual blood loss (range, 4–840 ml) and PGF, PGE, or 6-keto-PGF release in either endometrium or myometrium. Furthermore, there was no correlation between either the PGF to PGE2 or the PGF to 6-keto-PGF ratios and menstrual blood loss.

Original languageEnglish (US)
Pages (from-to)813-818
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume58
Issue number5
DOIs
StatePublished - May 1984

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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