Endorsement of self-report neurovegetative items of depression is associated with multiple sclerosis disease symptoms

Joe E. Beeney, Peter Andrew Arnett

Research output: Contribution to journalArticle

8 Scopus citations


Some researchers have suggested that general self-report depression scales may be inadequate for assessing depression among individuals with Multiple Sclerosis (MS), because many of such items represent MS disease symptoms. However, research has been mixed on this issue: whereas some studies provide support for symptom overlap, others have found opposing evidence. We investigated this issue in two different MS samples with three different strategies. We (1) examined reliable change in depression symptom categories at two time points over three years, (2) assessed the relationship between variables associated with depression and different depression symptom subscales, and (3) assessed the relationship between symptom subscales and physical disability. In each instance we found significant evidence that items meant to assess vegetative symptoms of depression may be influenced by presence of MS disease symptoms or were not associated with other core elements or central correlates of depression.

Original languageEnglish (US)
Pages (from-to)1057-1062
Number of pages6
JournalJournal of the International Neuropsychological Society
Issue number6
Publication statusPublished - Nov 10 2008


All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Clinical Psychology

Cite this