Endoscopic imaging of cerenkov luminescence

Sri Rajasekhar Kothapalli, Hongguang Liu, Joseph C. Liao, Zhen Cheng, Sanjiv Sam Gambhir

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43 Scopus citations


We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 μCi of radioactivity emitted from 18F-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with 18F-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging.

Original languageEnglish (US)
Pages (from-to)1215-1225
Number of pages11
JournalBiomedical Optics Express
Issue number6
StatePublished - Jun 1 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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    Kothapalli, S. R., Liu, H., Liao, J. C., Cheng, Z., & Gambhir, S. S. (2012). Endoscopic imaging of cerenkov luminescence. Biomedical Optics Express, 3(6), 1215-1225. https://doi.org/10.1364/BOE.3.001215