Endoscopic measurements of gastric mucosal blood flow in dogs

Stanley W. Ashley, Zhong Yu Yan, David I. Soybel, Laurence Y. Cheung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The feasibility and validity of endoscopic measurements of gastric mucosal blood flow (GMBF) using 3% H2 gas clearance were investigated in the intact stomach of anesthetized dogs. Platinum electrodes were lengthened and modified to permit passage through the instrument channel of a standard gastroscope. In five anesthetized dogs, antral mucosal blood flow (103.2 ± 5.3 ml/min/100 g tissue) was significantly higher (P < 0.05) than that in the corpus (66.9 ± 7.1 ml/min/100 g tissue). Histamine stimulation selectively increased flow in the corpus to 134.5 ± 7.5 ml/min/100 g tissue. Comparison of endoscopic GMBF measurements in these five dogs on 2 different days revealed a close correlation (r = 0.87, P < 0.001). Endoscopic H2 clearance measurements obtained in five awake dogs were not significantly different from those obtained during pentobarbitol anesthesia. In 12 dogs, GMBF determined by endoscopic H2 gas clearance showed a good agreement (r = 0.91, P < 0.001) with that measured by radioactive microspheres. These two methods also demonstrated comparable changes in GMBF induced by intravenous infusion of histamine and vasopressin. It was concluded that 3% H2 gas clearance can be used to accurately and reproducibly measure GMBF through the endoscope, a unique advantage of this method for potential clinical use.

Original languageEnglish (US)
Pages (from-to)416-423
Number of pages8
JournalJournal of Surgical Research
Volume38
Issue number5
DOIs
StatePublished - May 1985

Fingerprint

Stomach
Dogs
Gases
Histamine
Gastroscopes
Endoscopes
Platinum
Vasopressins
Microspheres
Intravenous Infusions
Electrodes
Anesthesia

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Ashley, Stanley W. ; Yan, Zhong Yu ; Soybel, David I. ; Cheung, Laurence Y. / Endoscopic measurements of gastric mucosal blood flow in dogs. In: Journal of Surgical Research. 1985 ; Vol. 38, No. 5. pp. 416-423.
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Endoscopic measurements of gastric mucosal blood flow in dogs. / Ashley, Stanley W.; Yan, Zhong Yu; Soybel, David I.; Cheung, Laurence Y.

In: Journal of Surgical Research, Vol. 38, No. 5, 05.1985, p. 416-423.

Research output: Contribution to journalArticle

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