Abstract
We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia (P <.001), chronic kidney disease (P =.004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells (P =.007) and was positively associated with height (P =.008). Furthermore, total distance walked during the 6-minute walk test was negatively associated with cultured endothelial cell NF-κB (P <.001), coronary artery disease (P =.009), and body mass index (P =.022) and was positively associated with ankle–brachial index (P <.001), male sex (P <.001), and hydroxyl radical antioxidant capacity (P <.001). The 6-minute walk performance in symptomatic patients with PAD was associated with vascular biomarkers, as walking distances were negatively associated with cultured endothelial cell inflammation and positively associated with circulating antioxidant capacity. The clinical implication is that behavioral interventions designed to alleviate endothelial cell inflammation and increase circulating antioxidant capacity, such as exercise and antioxidant intake, may improve ambulation of patients with PAD during submaximal exercise that is typically performed during daily activities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 416-423 |
| Number of pages | 8 |
| Journal | Angiology |
| Volume | 69 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2018 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease. / Gardner, Andrew; Montgomery, Polly S.; Zhao, Yan D.; Ungvari, Zoltan; Csiszar, Anna; Sonntag, William E.
In: Angiology, Vol. 69, No. 5, 01.05.2018, p. 416-423.Research output: Contribution to journal › Article
TY - JOUR
T1 - Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease
AU - Gardner, Andrew
AU - Montgomery, Polly S.
AU - Zhao, Yan D.
AU - Ungvari, Zoltan
AU - Csiszar, Anna
AU - Sonntag, William E.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia (P <.001), chronic kidney disease (P =.004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells (P =.007) and was positively associated with height (P =.008). Furthermore, total distance walked during the 6-minute walk test was negatively associated with cultured endothelial cell NF-κB (P <.001), coronary artery disease (P =.009), and body mass index (P =.022) and was positively associated with ankle–brachial index (P <.001), male sex (P <.001), and hydroxyl radical antioxidant capacity (P <.001). The 6-minute walk performance in symptomatic patients with PAD was associated with vascular biomarkers, as walking distances were negatively associated with cultured endothelial cell inflammation and positively associated with circulating antioxidant capacity. The clinical implication is that behavioral interventions designed to alleviate endothelial cell inflammation and increase circulating antioxidant capacity, such as exercise and antioxidant intake, may improve ambulation of patients with PAD during submaximal exercise that is typically performed during daily activities.
AB - We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia (P <.001), chronic kidney disease (P =.004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells (P =.007) and was positively associated with height (P =.008). Furthermore, total distance walked during the 6-minute walk test was negatively associated with cultured endothelial cell NF-κB (P <.001), coronary artery disease (P =.009), and body mass index (P =.022) and was positively associated with ankle–brachial index (P <.001), male sex (P <.001), and hydroxyl radical antioxidant capacity (P <.001). The 6-minute walk performance in symptomatic patients with PAD was associated with vascular biomarkers, as walking distances were negatively associated with cultured endothelial cell inflammation and positively associated with circulating antioxidant capacity. The clinical implication is that behavioral interventions designed to alleviate endothelial cell inflammation and increase circulating antioxidant capacity, such as exercise and antioxidant intake, may improve ambulation of patients with PAD during submaximal exercise that is typically performed during daily activities.
UR - http://www.scopus.com/inward/record.url?scp=85043319429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043319429&partnerID=8YFLogxK
U2 - 10.1177/0003319717726934
DO - 10.1177/0003319717726934
M3 - Article
C2 - 28835113
AN - SCOPUS:85043319429
VL - 69
SP - 416
EP - 423
JO - Angiology
JF - Angiology
SN - 0003-3197
IS - 5
ER -