TY - JOUR
T1 - Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease
AU - Gardner, Andrew W.
AU - Montgomery, Polly S.
AU - Zhao, Yan D.
AU - Ungvari, Zoltan
AU - Csiszar, Anna
AU - Sonntag, William E.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Supported by grants from the National Institute on Aging (R01-AG-24296 to AWG; R01-AG047879; R01-AG038747; 3P30AG050911-02S1to AC), the National Center for Complementary and Alternative Medicine (R01-AT006526 to ZU), the National Institute of Neurological Disorders and Stroke (NINDS; R01-NS056218 to AC), the Oklahoma Center for the Advancement of Science and Technology (to AWG, AC, and ZU), and General Clinical Research Center (M01-RR-14467), the American Heart Association (to AC and ZU), and the National Center for Complementary and Alternative Medicine (R01-AT006526 to ZU). Statistical analysis was supported by funding provided by National Institutes of Health, National Institute of General Medical Sciences, grant 1 U54GM104938.
Publisher Copyright:
© 2017, © The Author(s) 2017.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia (P <.001), chronic kidney disease (P =.004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells (P =.007) and was positively associated with height (P =.008). Furthermore, total distance walked during the 6-minute walk test was negatively associated with cultured endothelial cell NF-κB (P <.001), coronary artery disease (P =.009), and body mass index (P =.022) and was positively associated with ankle–brachial index (P <.001), male sex (P <.001), and hydroxyl radical antioxidant capacity (P <.001). The 6-minute walk performance in symptomatic patients with PAD was associated with vascular biomarkers, as walking distances were negatively associated with cultured endothelial cell inflammation and positively associated with circulating antioxidant capacity. The clinical implication is that behavioral interventions designed to alleviate endothelial cell inflammation and increase circulating antioxidant capacity, such as exercise and antioxidant intake, may improve ambulation of patients with PAD during submaximal exercise that is typically performed during daily activities.
AB - We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia (P <.001), chronic kidney disease (P =.004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells (P =.007) and was positively associated with height (P =.008). Furthermore, total distance walked during the 6-minute walk test was negatively associated with cultured endothelial cell NF-κB (P <.001), coronary artery disease (P =.009), and body mass index (P =.022) and was positively associated with ankle–brachial index (P <.001), male sex (P <.001), and hydroxyl radical antioxidant capacity (P <.001). The 6-minute walk performance in symptomatic patients with PAD was associated with vascular biomarkers, as walking distances were negatively associated with cultured endothelial cell inflammation and positively associated with circulating antioxidant capacity. The clinical implication is that behavioral interventions designed to alleviate endothelial cell inflammation and increase circulating antioxidant capacity, such as exercise and antioxidant intake, may improve ambulation of patients with PAD during submaximal exercise that is typically performed during daily activities.
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U2 - 10.1177/0003319717726934
DO - 10.1177/0003319717726934
M3 - Article
C2 - 28835113
AN - SCOPUS:85043319429
VL - 69
SP - 416
EP - 423
JO - Angiology
JF - Angiology
SN - 0003-3197
IS - 5
ER -