Endothelial-dependent flow-mediated dilation in african americans with masked-hypertension

Praveen Veerabhadrappa, Keith M. Diaz, Deborah L. Feairheller, Katie M. Sturgeon, Sheara T. Williamson, Deborah L. Crabbe, Abul M. Kashem, Michael D. Brown

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

BackgroundOffice-blood pressure (BP) measurements alone overlook a significant number of individuals with masked-hypertension (office-BP: 120/80-139/89mmHg and 24-h ambulatory BP monitoring (ABPM) daytime 135/85mmHg or night-time 120/70mmHg). Diminished endothelial function contributes to the pathogenesis of hypertension. To better understand the pathophysiology involved in the increased cardiovascular (CV) disease risk associated with masked-hypertension, we estimated the occurrence, assessed the endothelial function, compared plasma levels of inflammatory markers, white blood cell count (WBC count), tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hsCRP) and examined the possible relationship between endothelial function and inflammatory markers in apparently healthy prehypertensive (office-BP: 120/80-139/89mmHg) African Americans.MethodsFifty African Americans who were sedentary, nondiabetic, nonsmoking, devoid of CV disease were recruited. Office-BP was measured according to JNC-7 guidelines to identify prehypertensives in whom ABPM was then assessed. Fasting plasma samples were assayed for inflammatory markers. Brachial artery flow-mediated dilation (FMD) at rest and during reactive hyperemia was measured in a subset of prehypertensives.ResultsSubjects in the masked-hypertension sub-group had a higher hsCRP (P = 0.04) and diminished endothelial function (P = 0.03) compared to the true-prehypertensive sub-group (office-BP: 120/80-139/89mmHg and ABPM: daytime 135/85mmHg or night-time 120/70mmHg). Regression analysis showed that endothelial function was inversely related to hsCRP amongst the masked-hypertensive sub-group (R 2 = 0.160; P = 0.04).ConclusionsMasked- hypertension was identified in 58% of African Americans which suggests that a masking phenomenon may exist in a sub-group of prehypertensives who also seem to have a diminished endothelial function that could be mediated by an elevated subclinical inflammation leading to the increased CV disease.

Original languageEnglish (US)
Pages (from-to)1102-1107
Number of pages6
JournalAmerican journal of hypertension
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2011

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Veerabhadrappa, P., Diaz, K. M., Feairheller, D. L., Sturgeon, K. M., Williamson, S. T., Crabbe, D. L., Kashem, A. M., & Brown, M. D. (2011). Endothelial-dependent flow-mediated dilation in african americans with masked-hypertension. American journal of hypertension, 24(10), 1102-1107. https://doi.org/10.1038/ajh.2011.103