TY - JOUR
T1 - Endothelial function following interval exercise plus low-calorie diet treatment in obese females
AU - Gilbertson, Nicole M.
AU - Miller, Stephanie L.
AU - Eichner, Natalie Z.M.
AU - Malin, Steven K.
N1 - Funding Information:
Funding information Funding from the University of Virginia Thelma R. Swortzel Award, Curry School of Education, and Diabetes Action Research grant to S.K.M. supported this work. S.K.M is supported by United States National Institute of Health [RO1-HL130296]. We thank Emily Heiston, John Michael Pirtle, Julian Gaitán, Arthur Weltman, J. Hunter Mehaffey, and Taryn Hassinger for their help with the present study. We thank our collaborators in the Clinical Research Unit, Exercise Physiology Core Laboratory, and Ligand Assay and Analysis Core Laboratory for their contributions to data collection and analyte analysis. We thank our study participants for their excellent efforts.
Publisher Copyright:
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - We determined if interval exercise plus a low-calorie diet (LCD + INT) increases endothelial function more than an energy-matched LCD. Obese women (47.2 ± 2.6y, 37.5 ± 1.3kg/m2) were randomized to 13 days of a LCD (n = 12; mixed meals of ~ 1200kcal/d) or LCD + INT (n = 13; 12 supervised 60-min INT bouts of 3 min at 90% and 50% HRpeak). LCD + INT subjects received 350kcal postexercise to equate energy availability with LCD. Fitness (VO2peak) and body composition (BodPod) were determined and a 120 min, 75 g oral glucose tolerance test was performed to examine fasting and postprandial flow-mediated dilation (FMD, endothelial function), respiratory exchange ratio (RER) via indirect calorimetry as well as glucose and insulin incremental area under the curve (iAUC120min). LCD + INT increased VO2peak (P = 0.02) compared with LCD, and both treatments decreased fat mass (P < 0.001) and insulin iAUC120min (P = 0.03). There was no overall treatment effect on fasting or iAUC120min FMD. However, in participants who increased fasting endothelial function after each treatment (Δ > 50%; LCD n = 5, LCD + INT n = 7), LCD + INT increased fasted (P = 0.005) and decreased iAUC120min (P = 0.003) FMD compared with LCD. Enhanced fitness correlated with increased fasting FMD (r = 0.43, P = 0.03) and diminished FMD iAUC120min (r = −0.44, P = 0.03). Decreased FMD iAUC120min correlated with reduced glucose iAUC120min (r = 0.64, P = 0.001) as well as increased 60-min RER (r = −0.42, P = 0.04). Low baseline fasting and iAUC120min FMD was also linked to enhanced fasting and iAUC120min FMD post-treatment (r = −0.71, P < 0.001; r = −0.89, P < 0.001, respectively). In conclusion, increasing fitness via INT may increase the effect of LCD on lowering cardiovascular disease risk in obese women.
AB - We determined if interval exercise plus a low-calorie diet (LCD + INT) increases endothelial function more than an energy-matched LCD. Obese women (47.2 ± 2.6y, 37.5 ± 1.3kg/m2) were randomized to 13 days of a LCD (n = 12; mixed meals of ~ 1200kcal/d) or LCD + INT (n = 13; 12 supervised 60-min INT bouts of 3 min at 90% and 50% HRpeak). LCD + INT subjects received 350kcal postexercise to equate energy availability with LCD. Fitness (VO2peak) and body composition (BodPod) were determined and a 120 min, 75 g oral glucose tolerance test was performed to examine fasting and postprandial flow-mediated dilation (FMD, endothelial function), respiratory exchange ratio (RER) via indirect calorimetry as well as glucose and insulin incremental area under the curve (iAUC120min). LCD + INT increased VO2peak (P = 0.02) compared with LCD, and both treatments decreased fat mass (P < 0.001) and insulin iAUC120min (P = 0.03). There was no overall treatment effect on fasting or iAUC120min FMD. However, in participants who increased fasting endothelial function after each treatment (Δ > 50%; LCD n = 5, LCD + INT n = 7), LCD + INT increased fasted (P = 0.005) and decreased iAUC120min (P = 0.003) FMD compared with LCD. Enhanced fitness correlated with increased fasting FMD (r = 0.43, P = 0.03) and diminished FMD iAUC120min (r = −0.44, P = 0.03). Decreased FMD iAUC120min correlated with reduced glucose iAUC120min (r = 0.64, P = 0.001) as well as increased 60-min RER (r = −0.42, P = 0.04). Low baseline fasting and iAUC120min FMD was also linked to enhanced fasting and iAUC120min FMD post-treatment (r = −0.71, P < 0.001; r = −0.89, P < 0.001, respectively). In conclusion, increasing fitness via INT may increase the effect of LCD on lowering cardiovascular disease risk in obese women.
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U2 - 10.14814/phy2.14239
DO - 10.14814/phy2.14239
M3 - Article
C2 - 31552710
AN - SCOPUS:85072677614
SN - 2051-817X
VL - 7
JO - Physiological Reports
JF - Physiological Reports
IS - 18
M1 - e14239
ER -