Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice

Connie Jo Rogers, David Berrigan, David A. Zaharoff, Kenneth W. Hance, Arti C. Patel, Susan N. Perkins, Jeffrey Schlom, John W. Greiner, Stephen D. Hursting

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The prevalence of obesity, an established risk factor for several chronic diseases, including cancer, has risen dramatically over the past 4 decades. Dietary change and/or increased physical activity are the most commonly recommended lifestyle-based strategies for preventing or reversing obesity. One of several physiological systems that may be enhanced by dietary change and exercise is the immune system. In this study, we examined the effects of energy restriction (ER; 30% reduction relative to control energy intake) and/or exercise (EX; voluntary wheel running) on systemic and mucosal immune function. Female C57BL/6 mice were randomized into 4 treatment conditions: 1) controls consumed ad libitum (AL); 2) AL with access to running wheels (AL + EX); 3) 30% ER; and 4) 30% ER with access to running wheels (ER + EX). Both ER and EX reduced spleen weight and the number of splenic T and B lymphocytes (P < 0.05). ER enhanced natural killer (NK) cell function, but reduced concanavalin A (Con A)-induced T-cell proliferation (P < 0.05). In contrast, EX enhanced Con A-induced proliferation and cytokine production from Peyer's patch cells (P < 0.05). These data suggest that ER and EX enhance some, but not all, components of the immune system and are likely working via different biological mechanisms to regulate NK and T-cell function.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalJournal of Nutrition
Volume138
Issue number1
StatePublished - Jan 1 2008

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Mucosal Immunity
Running
Concanavalin A
Immune System
Obesity
T-Lymphocytes
Peyer's Patches
Natural Killer T-Cells
Energy Intake
Inbred C57BL Mouse
Natural Killer Cells
Life Style
B-Lymphocytes
Chronic Disease
Spleen
Cell Proliferation
Cytokines
Weights and Measures
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Rogers, C. J., Berrigan, D., Zaharoff, D. A., Hance, K. W., Patel, A. C., Perkins, S. N., ... Hursting, S. D. (2008). Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. Journal of Nutrition, 138(1), 115-122.
Rogers, Connie Jo ; Berrigan, David ; Zaharoff, David A. ; Hance, Kenneth W. ; Patel, Arti C. ; Perkins, Susan N. ; Schlom, Jeffrey ; Greiner, John W. ; Hursting, Stephen D. / Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. In: Journal of Nutrition. 2008 ; Vol. 138, No. 1. pp. 115-122.
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Rogers, CJ, Berrigan, D, Zaharoff, DA, Hance, KW, Patel, AC, Perkins, SN, Schlom, J, Greiner, JW & Hursting, SD 2008, 'Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice', Journal of Nutrition, vol. 138, no. 1, pp. 115-122.

Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. / Rogers, Connie Jo; Berrigan, David; Zaharoff, David A.; Hance, Kenneth W.; Patel, Arti C.; Perkins, Susan N.; Schlom, Jeffrey; Greiner, John W.; Hursting, Stephen D.

In: Journal of Nutrition, Vol. 138, No. 1, 01.01.2008, p. 115-122.

Research output: Contribution to journalArticle

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Rogers CJ, Berrigan D, Zaharoff DA, Hance KW, Patel AC, Perkins SN et al. Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. Journal of Nutrition. 2008 Jan 1;138(1):115-122.